ArticleNature biotechnology2024
BugSigDB captures patterns of differential abundance across a broad range of host-associated microbial signatures.
Article in Nature biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Pathology-derived clinical micro-architectural diagnostics of tumour-microbiome interactions in colorectal cancer.Journal of translational medicine · 2026Article
- Distinct signatures in the human gut and oral microbiomes of gastric cancer.Cell reports. Medicine · 2026Article
- Faecalibacterium prausnitzii, depleted in the Parkinson's disease microbiome, improves motor deficits in α-synuclein overexpressing mice.NPJ Parkinson's disease · 2026Article
- Interpreting Microbiome Signatures with MicrobiomeNet.Current protocols · 2026Article
- ResMicroDb: a comprehensive database and analysis platform for the human respiratory microbiome.Nucleic acids research · 2026Article
- A capsular polysaccharide from a healthy human microbiota member activates a Lag-3-NK cell axis to restrain colon cancer and augment immunotherapy.Cell reports · 2025Article
- MINERVA-microbiome network research and visualization atlas: a scalable knowledge graph for mapping microbiome-disease associations.Briefings in bioinformatics · 2025Article
- TaxSEA: rapid interpretation of microbiome alterations using taxon set enrichment analysis and public databases.Briefings in bioinformatics · 2025Article
- Elementary methods provide more replicable results in microbial differential abundance analysis.Briefings in bioinformatics · 2025Article
- MicrobiomeKG: bridging microbiome research and host health through knowledge graphs.Frontiers in systems biology · 2025Article
- lefser: implementation of metagenomic biomarker discovery tool, LEfSe, in R.Bioinformatics (Oxford, England) · 2024Article
- MicrobiomeKG: Bridging Microbiome Research and Host Health Through Knowledge Graphs.bioRxiv : the preprint server for biology · 2024Article
- Gut microbiome diversity withinmSystems · 2024Article
- biotextgraph: graphical summarization of functional similarities from textual information.Bioinformatics (Oxford, England) · 2024Article
- Challenges in IBD Research 2024: Preclinical Human IBD Mechanisms.Inflammatory bowel diseases · 2024Review
- Integrating biological knowledge for mechanistic inference in the host-associated microbiome.Frontiers in microbiology · 2024Review
- Microbial murmurs - decoding hidden conversations between bacteria.Nature reviews. Microbiology · 2024Article
Corrections and comments
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Authors and funding
21 authors.
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Abstract
The literature of human and other host-associated microbiome studies is expanding rapidly, but systematic comparisons among published results of host-associated microbiome signatures of differential abundance remain difficult. We present BugSigDB, a community-editable database of manually curated microbial signatures from published differential abundance studies accompanied by information on study geography, health outcomes, host body site and experimental, epidemiological and statistical methods using controlled vocabulary. The initial release of the database contains >2,500 manually curated signatures from >600 published studies on three host species, enabling high-throughput analysis of signature similarity, taxon enrichment, co-occurrence and coexclusion and consensus signatures. These data allow assessment of microbiome differential abundance within and across experimental conditions, environments or body sites. Database-wide analysis reveals experimental conditions with the highest level of consistency in signatures reported by independent studies and identifies commonalities among disease-associated signatures, including frequent introgression of oral pathobionts into the gut.
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