Evidence map›Paper›PMID 37697112›Full record

ArticleNature neuroscience2023

Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice.

Tsai-Yi Lu, Priyanka Hanumaihgari, Eric T Hsu, Amit Agarwal, Riki Kawaguchi, Peter A Calabresi, Dwight E Bergles

Open access · greenAbstract read
In one paragraph

Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pooled it
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  15. Glial Control of Cortical Neuronal Circuit Maturation and Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Review
  16. Review
  17. Article
  18. Review
  19. Exploring CaeNeuro · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Tsai-Yi LuSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-8818-6537
Priyanka HanumaihgariSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
Eric T HsuSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
Amit AgarwalSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-7948-4498
Riki KawaguchiDepartment of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.
Peter A CalabresiSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-7776-6472
Dwight E BerglesSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA. dbergles@jhmi.edu.ORCID http://orcid.org/0000-0002-7133-7378
Johns Hopkins University · USUniversity of California, Los Angeles · US

Funding

Murine Mutagenesis CoreP30NS050274 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KOLODKIN, ALEX L · 2005 to 2020
$10.9M
The Role of KV1.3 in Effector T cellsR01NS041435 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI CALABRESI, PETER A · 2000 to 2025
$5.8M
Training Program in NeuroscienceT32NS091018 · NINDS · JOHNS HOPKINS UNIVERSITY · PI JAMES J KNIERIM, Daniel Hans O'Connor · 2015 to 2026
$4.1M
Aging dependent transformation of oligodendrocyte precursor cellsR01AG072305 · NIA · JOHNS HOPKINS UNIVERSITY · PI BERGLES, DWIGHT E, GOFF, LOYAL ANDREW · 2021 to 2025
$2.0M
NIA NIH HHS R01 AG072305NINDS NIH HHS P30 NS050274NINDS NIH HHS R01 NS041435NINDS NIH HHS T32 NS091018
6 · The paper itself

Abstract

Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are generated from oligodendrocyte precursor cells (OPCs) that express neurotransmitter receptors. However, the mechanisms that affect OPC activity in vivo and the physiological roles of neurotransmitter signaling in OPCs are unclear. In this study, we generated a transgenic mouse line that expresses membrane-anchored GCaMP6s in OPCs and used longitudinal two-photon microscopy to monitor OPC calcium (Ca

Indexed as

Oligodendrocyte Precursor CellsAnimalsArousalCalciumCell DifferentiationCell ProliferationCerebral CortexMiceMice, TransgenicNorepinephrineOligodendrogliaCalciumNorepinephrine

Identifiers

PMID37697112
PMCPMC10630072
OpenAlexW4386610159

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.