ArticleNature chemistry2024
Carbonyl cross-metathesis via deoxygenative gem-di-metal catalysis.
Article in Nature chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The trial behind it
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Who cites it
10 citing papers in PubMed.
- Interfacial Proton Ordering Near the Electrode Surface Directs Carbonyl Electroreduction to Methylene.Angewandte Chemie (International ed. in English) · 2026Article
- Article
- Asymmetric Deoxygenative Difunctionalization of 1,2-Dicarbonyl Compounds Enabled by Phosphinite and Chiral Salen-Molybdenum Catalyst Synergy.Angewandte Chemie (International ed. in English) · 2026Article
- Catalytic Methods for the Transfer of Nonstabilized Carbenes.ACS catalysis · 2026Review
- Catalyst-controlled stereodivergent synthesis of polysubstituted alkenes.Nature communications · 2025Article
- Carbonyl-Olefin/Alkyne Metathesis Reactions Catalyzed by Bifunctional H-USY Zeolites.Journal of the American Chemical Society · 2025Article
- General Modular and Convergent Approach to Diversely Functionalized Allylic Systems.Journal of the American Chemical Society · 2025Article
- Visible-light-mediated deoxygenative transformation of 1,2-dicarbonyl compounds through energy transfer process.Nature communications · 2024Article
- Article
- Stereoselective Copper-Catalyzed Olefination of Imines.Angewandte Chemie (International ed. in English) · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Carbonyls and alkenes are versatile functional groups, whose reactivities are cornerstones of organic synthesis. The selective combination of two carbonyls to form an alkene-a carbonyl cross-metathesis-would be a valuable tool for their exchange. Yet, this important synthetic challenge remains unsolved. Although alkene/alkene and alkene/carbonyl cross-metathesis reactions are known, there is a lack of analogous methods for deoxygenative cross-coupling of two carbonyl compounds. Here we report a pair of strategies for the cross-metathesis of unbiased carbonyls, allowing an aldehyde to be chemo- and stereoselectively combined with another aldehyde or ketone. These mild, catalytic methods are promoted by earth-abundant metal salts and enable rapid access to an unprecedentedly broad range of either Z- or E-alkenes by two distinct mechanisms-entailing transiently generated (1) carbenes and ylides (via Fe catalysis) or (2) doubly nucleophilic gem-di-metallics (via Cr catalysis).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.