ReviewNature reviews. Endocrinology2023
Obesity-induced and weight-loss-induced physiological factors affecting weight regain.
Review in Nature reviews. Endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it, 69 citations in OpenAlex.
- Trajectory of the body weight after drug discontinuation in the treatment of anti-obesity medications.BMC medicine · 2025Pooled it
- Intragastric Balloon Treatment Enhances Weight Maintenance Adjunct to Low-Energy Diet and Group-Based Cognitive Behavioural Therapy: A Randomized Controlled Trial.Diabetes, obesity & metabolism · 2026Trial
- Long-term effects of dietary protein and carbohydrate quality on prediabetes remission: results from the PREVIEW randomised multinational diabetes prevention trial.Diabetologia · 2026Trial
- Time to weight plateau with tirzepatide treatment in the SURMOUNT-1 and SURMOUNT-4 clinical trials.Clinical obesity · 2025Trial
- A novel approach to fat reduction: integrating traditional Chinese medicine with a dissolving MNs.Drug delivery and translational research · 2026Article
- Long-term weight maintenance after a low-carbohydrate diet: a real-world retrospective cohort study.European journal of clinical nutrition · 2026Article
- LOX-mediated adipose tissue stiffening promotes weight rebound.Journal of lipid research · 2026Article
- Long-Term Weight Variability Is Associated with Higher Triglyceride Concentrations After Accounting for Long-Term Weight Slope.Nutrients · 2026Article
- Weight regain after obesity treatment: mechanisms, predictors, and real-world evidence from the IGOBE program.Reviews in endocrine & metabolic disorders · 2026Review
- Adolescent obesity induces sex-specific alterations of action control.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Neural Decision-Making and Affective Dynamics in Weight Regain after Metabolic and Bariatric Surgery: A Multimodal Longitudinal Computational Psychiatry Study.Obesity surgery · 2026Article
- Review
- Influence of Biological Sex on Metabolic and Adipokine Responses after Metabolic-Bariatric Surgery: A Narrative Review.Current obesity reports · 2026Review
- Dynamic interplay between food addiction, psychological and behavioral factors, and weight-related measures: A longitudinal network analysis in developing youth.Journal of behavioral addictions · 2026Article
- The impact of glucagon-like peptide-1 receptor agonists on objective physical activity in adults: a systematic review and exploratory meta-analysis.International journal of obesity (2005) · 2026Review
- Review
- Review
- PKCβ II antagonizes O-GlcNAcylated FOXO4 and inhibits lipid synthesis.Apoptosis : an international journal on programmed cell death · 2026Article
- Article
- Intelligence-driven Mechanomedicine for Weight Rebound in Obesity.Current obesity reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Weight regain after successful weight loss resulting from lifestyle interventions is a major challenge in the management of overweight and obesity. Knowledge of the causal mechanisms for weight regain can help researchers and clinicians to find effective strategies to tackle weight regain and reduce obesity-associated metabolic and cardiovascular complications. This Review summarizes the current understanding of a number of potential physiological mechanisms underlying weight regain after weight loss, including: the role of adipose tissue immune cells; hormonal and neuronal factors affecting hunger, satiety and reward; resting energy expenditure and adaptive thermogenesis; and lipid metabolism (lipolysis and lipid oxidation). We describe and discuss obesity-associated changes in these mechanisms, their persistence during weight loss and weight regain and their association with weight regain. Interventions to prevent or limit weight regain based on these factors, such as diet, exercise, pharmacotherapy and biomedical strategies, and current knowledge on the effectiveness of these interventions are also reviewed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.