Evidence map›Paper›PMID 37696893›Full record

ReviewExperimental & molecular medicine2023

Unconventional immune cells in the gut mucosal barrier: regulation by symbiotic microbiota.

Ji-Sun Yoo, Sungwhan F Oh

Open access · goldAbstract readReview
In one paragraph

Review in Experimental & molecular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
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  3. Intestinal-Bone Axis Mediated byMicroorganisms · 2026
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  12. Emerging Mechanistic Links Between Fucosylation and Senescence in Lung Diseases.Journal of respiratory biology and translational medicine · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ji-Sun YooCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Sungwhan F OhCenter for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA, USA. soh2@bwh.harvard.edu.ORCID 0000-0002-0280-7903
Brigham and Women's Hospital · US

Funding

Gut symbiotic microbiota-derived CD1d ligands and their immunomodulatory mechanismsR01AI165987 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI OH, SUNGWHAN F · 2022 to 2025
$2.7M
Contribution of phytochemicals to gut symbiont colonization and synthesis of immunomodulatory sphingolipidsR01AT010268 · NCCIH · BRIGHAM AND WOMEN'S HOSPITAL · PI OH, SUNGWHAN F · 2019 to 2022
$1.8M
NCCIH NIH HHS R01 AT010268NIAID NIH HHS R01 AI165987
6 · The paper itself

Abstract

The mammalian gut is the most densely colonized organ by microbial species, which are in constant contact with the host throughout life. Hosts have developed multifaceted cellular and molecular mechanisms to distinguish and respond to benign and pathogenic bacteria. In addition to relatively well-characterized innate and adaptive immune cells, a growing body of evidence shows additional important players in gut mucosal immunity. Among them, unconventional immune cells, including innate lymphoid cells (ILCs) and unconventional T cells, are essential for maintaining homeostasis. These cells rapidly respond to bacterial signals and bridge the innate immunity and adaptive immunity in the mucosal barrier. Here, we focus on the types and roles of these immune cells in physiological and pathological conditions as prominent mechanisms by which the host immune system communicates with the gut microbiota in health and diseases.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAnimalsBacteriaImmunity, InnateImmunity, MucosalIntestinal MucosaLymphocytesMammals

Identifiers

PMID37696893
PMCPMC10545787
OpenAlexW4386606763

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.