Evidence map›Paper›PMID 37696869›Full record

ArticleNature communications2023

Contribution of common and rare variants to Asian neovascular age-related macular degeneration subtypes.

Qiao Fan, Hengtong Li, Xiaomeng Wang, Yih-Chung Tham, Kelvin Yi Chong Teo, Masayuki Yasuda, Weng Khong Lim, Yuet Ping Kwan, Jing Xian Teo, Ching-Jou Chen and 12 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 13 institutions in 5 countries.

Qiao Fan *Center for Quantitative Medicine, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore. qiao.fan@duke-nus.edu.sg.ORCID http://orcid.org/0000-0002-2762-8346
Hengtong Li *Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.ORCID http://orcid.org/0000-0002-3843-7174
Xiaomeng Wang *Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.ORCID http://orcid.org/0000-0002-1036-2764
Yih-Chung ThamOphthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
Kelvin Yi Chong TeoOphthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.ORCID http://orcid.org/0000-0002-7458-7081
Masayuki YasudaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan.
Weng Khong LimSingHealth Duke-NUS Institute of Precision Medicine, Singapore, Singapore.ORCID http://orcid.org/0000-0003-4391-1130
Yuet Ping KwanOphthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
Jing Xian TeoSingHealth Duke-NUS Institute of Precision Medicine, Singapore, Singapore.
Ching-Jou ChenCenter for Vision Research, Duke-NUS Medical School, National University of Singapore, Singapore, Singapore.
Li Jia ChenDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Jeeyun AhnDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea.
Sonia DavilaSingHealth Duke-NUS Institute of Precision Medicine, Singapore, Singapore.
Masahiro MiyakeDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.ORCID http://orcid.org/0000-0001-7410-3764
Patrick TanSingHealth Duke-NUS Institute of Precision Medicine, Singapore, Singapore.ORCID http://orcid.org/0000-0002-0179-8048
Kyu Hyung ParkDepartment of Ophthalmology, Seoul National University Hospital, Seoul, Korea.
Chi Pui PangDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
Chiea Chuan KhorHuman Genetics, Genome Institute of Singapore, Singapore, Singapore.ORCID http://orcid.org/0000-0002-1128-4729
Tien Yin WongTsinghua Medicine, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0002-8448-1264
Yasuo YanagiDepartment of Ophthalmology and Microtechnology, Yokohama City University, Yokohama, Japan.
Chui Ming Gemmy CheungOphthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
Ching-Yu ChengOphthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. chingyu.cheng@duke-nus.edu.sg.ORCID http://orcid.org/0000-0003-0655-885X
National University of Singapore · SGSingHealth · SGChinese University of Hong Kong · HKSingapore National Eye Center · SGAgency for Science, Technology and Research · SGDuke-NUS Medical School · SGGenome Institute of Singapore · SGKyoto University · JPSeoul National University · KRSeoul National University Hospital · KRTohoku University · JPTsinghua University · CNYokohama City University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neovascular age-related macular degeneration (nAMD), along with its clinical subtype known as polypoidal choroidal vasculopathy (PCV), are among the leading causes of vision loss in elderly Asians. In a genome-wide association study (GWAS) comprising 3,128 nAMD (1,555 PCV and 1,573 typical nAMD), and 5,493 controls of East Asian ancestry, we identify twelve loci, of which four are novel ([Formula: see text]). Substantial genetic sharing between PCV and typical nAMD is noted (r

Indexed as

Macular DegenerationPolypoidal Choroidal VasculopathyAgedAnimalsAsianDisease Models, AnimalEast Asian PeopleExtracellular MatrixGenome-Wide Association StudyHumansMice

Identifiers

PMID37696869
PMCPMC10495468
OpenAlexW4386607142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.