ArticleNature communications2023
Single-cell transcriptome analysis indicates fatty acid metabolism-mediated metastasis and immunosuppression in male breast cancer.
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Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54citing papers in PubMed
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54 citing papers in PubMed, 59 citations in OpenAlex.
- DONSON links tumor-cell survival to MIF-associated macrophage remodeling in small cell lung cancer.Apoptosis : an international journal on programmed cell death · 2026Article
- Multiplatform single-cell and spatial transcriptomics reveal sex-specific malignant states and architecture in male breast cancer.Science advances · 2026Article
- Review
- Decoding age-stratified clinical and molecular heterogeneity in male breast cancer through multiomic profiling.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026Article
- Single-Cell Analysis Reveals STARD10 as a Fatty Acid Metabolism Regulator of Breast Cancer Progression via the PI3K/Akt Pathway.International journal of molecular sciences · 2026Article
- Cigarette smoke induces FASN-dependent fatty acid metabolic rewiring to drive bladder cancer progression.Cancer letters · 2026Article
- Multiomic and functional validation of ACSL3, a regulator of fatty acid metabolism, as a lymph node metastasis-associated gene in lung adenocarcinoma.Respiratory research · 2026Article
- Single-cell RNA sequencing reveals HMGA2 involvement in neoplastic aggressiveness and endothelial cell senescence in chondrosarcoma.Cell biology and toxicology · 2026Article
- Transcriptomic deconvolution reveals prognostic immune signatures and immunotherapy-responsive subtypes in male breast cancer.Breast cancer research : BCR · 2026Article
- The evidence for the use of peripheral blood indices in the diagnosis of breast cancer.The Journal of international medical research · 2026Review
- Metabolic reprogramming in cancer: signaling pathways and therapeutic targets.Molecular cancer · 2026Review
- The Role of Lipid Metabolism in the Progression of Breast Cancer.Journal of Cancer · 2026Review
- Integrative single-cell and bulk transcriptomics uncovers a lipid metabolism-related lncRNA signature alongside the ELFN1-AS1/LYPLA1 axis driving osteosarcoma progression.Frontiers in immunology · 2026Article
- Case Report: long-term survival of a male patient with breast cancer complicated by lung adenocarcinoma treated with individualized therapy.Frontiers in oncology · 2026Article
- Gene signatures of palmitoylation and fatty acid metabolism predict prognosis and immunotherapy response in breast cancer patients by machine learning, single-cell analysis, and experimental validation.Frontiers in pharmacology · 2026Article
- Dual targeting of lipid metabolic reprogramming and immunosuppressive sentinel lymph nodes potentiates anti-metastatic therapy for triple negative breast cancer.Bioactive materials · 2026Article
- Co-targeting ferroptosis and immune evasion through small molecules in breast cancer.Journal of translational internal medicine · 2025Article
- Article
- SPP1 + macrophage and Treg interaction mediates immunosuppression and adverse survival in HER2 + breast cancer.Scientific reports · 2025Article
- FASN inhibits ferroptosis in breast cancer via USP5 palmitoylation-dependent regulation of GPX4 deubiquitination.Journal of experimental & clinical cancer research : CR · 2025Article
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Authors and funding
43 authors at 11 institutions in 2 countries.
Handong Sun *Jiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China.
Lishen Zhang *Department of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.
Zhonglin Wang *Department of Breast Surgery, The Second People's Hospital of Lianyungang, 41 Hailian East Road, 222006, Lianyungang, China.
Danling Gu *National Health Commission Key Laboratory of Antibody Techniques, Department of Cell Biology, Jiangsu Provincial Key Laboratory of Human Functional Genomics, School of Basic Medical Sciences, Nanjing Medical University, 211166, Nanjing, Jiangsu, China.
Mengyan ZhuDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.
Yun CaiDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.
Lu LiDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.
Jiaqi TangDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.
Bin HuangDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.
Bakwatanisa BoscoDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.ORCID http://orcid.org/0000-0001-5007-0240
Ning LiDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.
Lingxiang WuDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.
Wei WuDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.
Liangyu LiDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.
Yuan LiangDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.ORCID http://orcid.org/0000-0002-9143-9670
Lin LuoDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.
Quanzhong LiuDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China.
Yanhui ZhuJiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China.
Jie SunDepartment of Breast Surgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, 215006, Suzhou, China.
Liang ShiJiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China.
Tiansong XiaJiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China.
Chuang YangJiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China.
Qitong XuJiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China.
Xue HanDepartment of Pathology, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China.
Weiming ZhangDepartment of Pathology, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China.
Jianxia LiuDepartment of Breast Surgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, 215006, Suzhou, China.
Dong MengDepartment of Breast Surgery, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, 214000, Wuxi, China.
Hua ShaoDepartment of Breast Surgery, The Second People's Hospital of Lianyungang, 41 Hailian East Road, 222006, Lianyungang, China.
Xiangxin ZhengDepartment of Breast Surgery, Affiliated Suqian Hospital of Xuzhou Medical University, 138 Huanghe South Road, 223800, Suqian, China.
Shuqin LiThe Affiliated Lianyungang Hospital of Xuzhou Medical University, 6 Zhenhua East Road, 222006, Lianyungang, China.
Hua PanLiyang People's Hospital, 70 Jianshe West Road, 213300, Liyang, China.
Jing KeThe Affiliated Hospital of Nantong University, 20 Xisi Road, 226300, Nantong, China.
Wenying JiangDepartment of Breast Surgery, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, 213000, Changzhou, China.
Xiaolan ZhangDepartment of Breast Surgery, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, 29 Xinglong Lane, 213000, Changzhou, China.
Xuedong HanDepartment of Breast and Thyroid Surgery, Huai'an First People's Hospital, Nanjing Medical University, 1 Huanghe West Road, 223300, Huai'an, China.
Jian ChuDepartment of General Surgery, the First People's Hospital of Yancheng, 66 Renmin South Road, 224001, Yancheng, China.
Hongyin AnDepartment of General Surgery, the First People's Hospital of Yancheng, 66 Renmin South Road, 224001, Yancheng, China.
Juyan GeDepartment of Pathology, The Second People's Hospital of Lianyungang, 41 Hailian East Road, 222006, Lianyungang, China.
Chi PanDepartment of Breast Surgery, the Second Affiliated Hospital, Zhejiang University, College of Medicine, 88 Jiefang Road, 310009, Hangzhou, China.
Xiuxing WangNational Health Commission Key Laboratory of Antibody Techniques, Department of Cell Biology, Jiangsu Provincial Key Laboratory of Human Functional Genomics, School of Basic Medical Sciences, Nanjing Medical University, 211166, Nanjing, Jiangsu, China.ORCID http://orcid.org/0000-0001-7115-729X
Kening LiDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China. likening@njmu.edu.cn.ORCID http://orcid.org/0000-0001-9750-1810
Qianghu WangDepartment of Bioinformatics, Nanjing Medical University, 101 Longmian Avenue, 211166, Nanjing, China. wangqh@njmu.edu.cn.ORCID http://orcid.org/0000-0002-3488-1059
Qiang DingJiangsu Breast Disease Center, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, China. dingqiang@njmu.edu.cn.ORCID http://orcid.org/0000-0003-1499-6200
Jiangsu Cancer Hospital · CNNanjing Medical University · CNNantong University · CNSoochow University · CNThe First People’s Hospital of Lianyungang · CNHuaian First People’s Hospital · CNXuzhou Medical College · CNChangzhou No.2 People's Hospital · CNJiangnan University · CNSecond Affiliated Hospital of Zhejiang University · CNUniversity of California San Diego · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Male breast cancer (MBC) is a rare but aggressive malignancy with cellular and immunological characteristics that remain unclear. Here, we perform transcriptomic analysis for 111,038 single cells from tumor tissues of six MBC and thirteen female breast cancer (FBC) patients. We find that that MBC has significantly lower infiltration of T cells relative to FBC. Metastasis-related programs are more active in cancer cells from MBC. The activated fatty acid metabolism involved with FASN is related to cancer cell metastasis and low immune infiltration of MBC. T cells in MBC show activation of p38 MAPK and lipid oxidation pathways, indicating a dysfunctional state. In contrast, T cells in FBC exhibit higher expression of cytotoxic markers and immune activation pathways mediated by immune-modulatory cytokines. Moreover, we identify the inhibitory interactions between cancer cells and T cells in MBC. Our study provides important information for understanding the tumor immunology and metabolism of MBC.
Indexed as
Breast Neoplasms, MaleFatty AcidsFemaleHumansImmunosuppression TherapyLipid MetabolismMaleSingle-Cell Gene Expression AnalysisFatty Acids
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