ArticleNature communications2023
The spatial and temporal structure of neural activity across the fly brain.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Inferring brain-wide interactions using data-constrained recurrent neural network models.Neuron · 2026Article
- Protocol for simultaneous in vivo two-photon imaging and locomotion quantification during olfactory stimulation and pharmacology in walking Drosophila.STAR protocols · 2026Article
- High-speed whole-brain imaging in Drosophila.Nature communications · 2026Article
- Astrocyte-induced internal state transitions reshape brainwide sensory, integrative, and motor computations.bioRxiv : the preprint server for biology · 2026Article
- Short-term memory by distributed neural network oscillators in a simple nervous system.Current biology : CB · 2025Article
- Integrative functional optical imaging approaches: Optics, microfluidics, and machine learning for neuroscience in organoids and small-animal models.Biophysical journal · 2025Review
- Prominent involvement of acetylcholine dynamics in stable olfactory representation across the Drosophila brain.Nature communications · 2025Article
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- Structural and genetic determinants of zebrafish functional brain networks.Science advances · 2025Article
- Article
- Structure of activity in multiregion recurrent neural networks.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The influence of emotion on temporal context models.Cognition & emotion · 2025Review
- Coordination and persistence of aggressive visual communication in Siamese fighting fish.Cell reports · 2025Article
- Article
- BIFROST: A method for registering diverse imaging datasets of theProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Mesoscale Brain Mapping: Bridging Scales and Modalities in Neuroimaging - A Symposium Review.Neuroinformatics · 2024Review
- Building and integrating brain-wide maps of nervous system function in invertebrates.Current opinion in neurobiology · 2024Review
- Simultaneous, cortex-wide and cellular-resolution neuronal population dynamics reveal an unbounded scaling of dimensionality with neuron number.bioRxiv : the preprint server for biology · 2024Article
- A study of animal action segmentation algorithms across supervised, unsupervised, and semi-supervised learning paradigms.Neurons, behavior, data analysis, and theory · 2024Article
- Brain-wide representations of behavior spanning multiple timescales and states in C. elegans.Cell · 2023Article
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12 authors.
Funding
Abstract
What are the spatial and temporal scales of brainwide neuronal activity? We used swept, confocally-aligned planar excitation (SCAPE) microscopy to image all cells in a large volume of the brain of adult Drosophila with high spatiotemporal resolution while flies engaged in a variety of spontaneous behaviors. This revealed neural representations of behavior on multiple spatial and temporal scales. The activity of most neurons correlated (or anticorrelated) with running and flailing over timescales that ranged from seconds to a minute. Grooming elicited a weaker global response. Significant residual activity not directly correlated with behavior was high dimensional and reflected the activity of small clusters of spatially organized neurons that may correspond to genetically defined cell types. These clusters participate in the global dynamics, indicating that neural activity reflects a combination of local and broadly distributed components. This suggests that microcircuits with highly specified functions are provided with knowledge of the larger context in which they operate.
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