Evidence map›Paper›PMID 37696579›Full record

ArticleLife science alliance2023

Control of Paneth cell function by HuR regulates gut mucosal growth by altering stem cell activity.

Lan Xiao, Bridgette Warner, Caroline G Mallard, Hee K Chung, Amol Shetty, Christine A Brantner, Jaladanki N Rao, Gregory S Yochum, Walter A Koltun, Kathleen B To and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Long Noncoding RNANon-coding RNA · 2026
    Article
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  3. Article
  4. Article
  5. Review
  6. Review
  7. Polyamines regulate mitochondrial metabolism essential for intestinal epithelial renewal and wound healing.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Lan XiaoCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Bridgette WarnerCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Caroline G MallardCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Hee K ChungCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Amol ShettyInstitute for Genome Science, University of Maryland School of Medicine, Baltimore, MD, USA.
Christine A BrantnerElectron Microscopy Core Imaging Facility, University of Maryland Baltimore, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-8172-901X
Jaladanki N RaoCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Gregory S YochumDepartment of Surgery, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Walter A KoltunDepartment of Surgery, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Kathleen B ToBaltimore Veterans Affairs Medical Center, Baltimore, MD, USA.
Douglas J TurnerCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Myriam GorospeLaboratory of Genetics and Genomics, National Institute on Aging-IRP, NIH, Baltimore, MD, USA.
Jian-Ying WangCell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA jywang@som.umaryland.edu.ORCID https://orcid.org/0000-0003-3002-1040
University of Maryland, Baltimore · USPennsylvania State University · USNational Institute on Aging · USUniversity of Baltimore · USVeterans Health Administration · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rapid self-renewal of the intestinal epithelium requires the activity of intestinal stem cells (ISCs) that are intermingled with Paneth cells (PCs) at the crypt base. PCs provide multiple secreted and surface-bound niche signals and play an important role in the regulation of ISC proliferation. Here, we show that control of PC function by RNA-binding protein HuR via mitochondria affects intestinal mucosal growth by altering ISC activity. Targeted deletion of HuR in mice disrupted PC gene expression profiles, reduced PC-derived niche factors, and impaired ISC function, leading to inhibited renewal of the intestinal epithelium. Human intestinal mucosa from patients with critical surgical disorders exhibited decreased levels of tissue HuR and PC/ISC niche dysfunction, along with disrupted mucosal growth. HuR deletion led to mitochondrial impairment by decreasing the levels of several mitochondrial-associated proteins including prohibitin 1 (PHB1) in the intestinal epithelium, whereas HuR enhanced PHB1 expression by preventing microRNA-195 binding to the

Indexed as

ELAV-Like Protein 1MicroRNAsMucous MembranePaneth CellsAnimalsBiological TransportCell Physiological PhenomenaHumansIntestinal MucosaMiceMitochondrial ProteinsStem CellsELAVL1 protein, humanELAV-Like Protein 1MicroRNAsMIRN195 microRNA, humanMitochondrial Proteins

Identifiers

PMID37696579
PMCPMC10494932
OpenAlexW4386601126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.