Evidence map›Paper›PMID 37696137›Full record

ArticleJournal of molecular and cellular cardiology2023

Loss of cyclophilin D prolyl isomerase activity desensitizes mitochondrial permeability transition pore opening in isolated cardiac mitochondria, but does not protect in myocardial ischemia-reperfusion injury.

Kevin M Casin, Moises Bustamante, Georgios Amanakis, Junhui Sun, Chengyu Liu, Richard N Kitsis, Elizabeth Murphy

Open access · greenAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Dl-3-ACS chemical neuroscience · 2025
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kevin M CasinLaboratory of Cardiac Physiology, Cardiovascular Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA. Electronic address: CasinKM@nih.gov.
Moises BustamanteLaboratory of Cardiac Physiology, Cardiovascular Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.
Georgios AmanakisLaboratory of Cardiac Physiology, Cardiovascular Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.
Junhui SunLaboratory of Cardiac Physiology, Cardiovascular Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.
Chengyu LiuTransgenic Core, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, 20892, USA.
Richard N KitsisDeptartment of Medicine, Albert Einstein College of Medicine and Cell Biology and Wilf Family Cardiovascular Research Institute, Bronx, NY 10461, USA.
Elizabeth MurphyLaboratory of Cardiac Physiology, Cardiovascular Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.
National Heart Lung and Blood Institute · USAlbert Einstein College of Medicine · US

Funding

Mechanisms of cardiac ischemia-reperfusion injury and cardioprotectionZIAHL002066 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2009 to 2025
$20.4M
Mechanisms of cardiac ischemia-reperfusion injury and cardioprotectionZ01HL002066 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MURPHY, ELIZABETH · 2008 to 2008
$607k
Intramural NIH HHS Z01 HL002066Intramural NIH HHS ZIA HL002066
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Mitochondrial Permeability Transition PoreMyocardial Reperfusion InjuryCyclophilinsCyclosporineHumansMitochondria, HeartMitochondrial Membrane Transport ProteinsPeptidyl-Prolyl Isomerase FPermeabilityCyclophilinsCyclosporineMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PorePeptidyl-Prolyl Isomerase FCyclophilin DCyclosporine AIschemia-reperfusion injuryMitochondria permeability transition poreProlyl isomerase

Identifiers

PMID37696137
PMCPMC10809717
OpenAlexW4386565588

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.