ArticleIEEE transactions on bio-medical engineering2024
Device for Multifocal Delivery of Ultrasound Into Deep Brain Regions in Humans.
Article in IEEE transactions on bio-medical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Ultrasound Applications in the Treatment of Major Depressive Disorder: A Systematic Review of Techniques and Therapeutic Potentials in Clinical Trials and Animal Model Studies.Neuromodulation : journal of the International Neuromodulation Society · 2026Pooled it
- Transcranial ultrasound stimulation parameters for neurological diseases: a systematic review.Frontiers in neurology · 2025Pooled it
- Noninvasive Modulation of the Subcallosal Cingulate and Depression With Focused Ultrasonic Waves.Biological psychiatry · 2025Trial
- Flexible bioelectronic sensors promote the advancement of wearable ultrasound technology in the medicine.Microsystems & nanoengineering · 2026Review
- Low-intensity transcranial ultrasound neuromodulation promotes neuronal regeneration: A new hope for noninvasive treatment of neurodegenerative diseases.Neural regeneration research · 2026Article
- Performance of a through-transmit aberration correction method for transcranial focused ultrasound: Simulation and experimental evaluation.The Journal of the Acoustical Society of America · 2026Article
- Antidepressant effect of transcranial pulse stimulation (TPS) targeting neuropsychiatric disorders: a retrospective analysis.Psychological medicine · 2026Article
- Translational prospectives for deep brain stimulation and low-intensity focused ultrasound neuromodulation: IFCN Handbook chapter.Clinical neurophysiology practice · 2026Review
- Quiet waves, deep impact: acoustic modeling of low-intensity focused ultrasound.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Role of thalamus in human conscious perception revealed by low-intensity focused ultrasound neuromodulation.Nature communications · 2025Article
- Influence of bone microstructure on ultrasound loss through skull-mimicking digital phantoms.Medical physics · 2025Article
- Multitarget neurostimulation of the deep brain: clinical opportunities, challenges, and emerging technologies.Journal of neural engineering · 2025Review
- A panoramic review of transcranial focused ultrasound neuromodulation: from basic research to clinical applications.Journal of neuroengineering and rehabilitation · 2025Review
- Using Low-Intensity Focused Ultrasound to Treat Depression and Anxiety Disorders: A Review of Current Evidence.Brain sciences · 2025Review
- Ultrasound system for precise neuromodulation of human deep brain circuits.Nature communications · 2025Article
- Optimizing healthcare big data performance through regional computing.Scientific reports · 2025Article
- A review of functional neuromodulation in humans using low-intensity transcranial focused ultrasound.Biomedical engineering letters · 2024Review
- Controlled ultrasonic interventions through the human skull.Frontiers in human neuroscience · 2024Article
- Targeted drug release from stable and safe ultrasound-sensitive nanocarriers.Frontiers in molecular biosciences · 2024Article
- Durable effects of deep brain ultrasonic neuromodulation on major depression: a case report.Journal of medical case reports · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Low-intensity focused ultrasound provides the means to noninvasively stimulate or release drugs in specified deep brain targets. However, successful clinical translations require hardware that maximizes acoustic transmission through the skull, enables flexible electronic steering, and provides accurate and reproducible targeting while minimizing the use of MRI. We have developed a device that addresses these practical requirements. The device delivers ultrasound through the temporal and parietal skull windows, which minimize the attenuation and distortions of the ultrasound by the skull. The device consists of 252 independently controlled elements, which provides the ability to modulate multiple deep brain targets at a high spatiotemporal resolution, without the need to move the device or the subject. And finally, the device uses a mechanical registration method that enables accurate deep brain targeting both inside and outside of the MRI. Using this method, a single MRI scan is necessary for accurate targeting; repeated subsequent treatments can be performed reproducibly in an MRI-free manner. We validated these functions by transiently modulating specific deep brain regions in two patients with treatment-resistant depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.