Evidence map›Paper›PMID 37695430›Full record

ArticleCurrent topics in microbiology and immunology2023

Sex Difference in Amebiasis.

Marco Er-Lukowiak, Charlotte Hansen, Hanna Lotter

Abstract read
PubMed Publisher
In one paragraph

Article in Current topics in microbiology and immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Marco Er-LukowiakDepartment Interface - RG Molecular Infection Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Charlotte HansenDepartment Interface - RG Molecular Infection Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
Hanna LotterDepartment Interface - RG Molecular Infection Immunology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany. Iotter@bnitm.de.
Bernhard Nocht Institute for Tropical Medicine · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infection with the protozoan parasite Entamoeba histolytica is much more likely to cause severe, focal liver damage in males than females, although the infection rate is the same in both sexes. The differences in disease susceptibility may be due to modulation of key mechanisms of the innate immune response by sex hormones. Complement-mediated mechanisms and estrogen-dependent activated natural killer T cells lead to early elimination of the parasite in females, whereas a pathological immune axis is triggered in males. Testosterone, which is generally thought to have more immunosuppressive properties on cells of the immune response, leads to overwhelming activation of monocytes and host-dependent destruction of liver tissue in males resulting in worse outcomes.

Indexed as

AmebiasisSex CharacteristicsFemaleHumansImmunity, InnateLiverMaleEntamoeba histolyticaHepatic amebiasisImmune responseMale biasSex hormones

Identifiers

PMID37695430
OpenAlexW4386592002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.