Evidence map›Paper›PMID 37695126›Full record

ArticleMicrobiology spectrum2023

Pronounced gut microbiota signatures in patients with

Christina Schjellerup Eickhardt-Dalbøge, Anna Cäcilia Ingham, Henrik V Nielsen, Kurt Fuursted, Christen Rune Stensvold, Lee O'Brien Andersen, Morten Kranker Larsen, Lasse Kjær, Sarah Friis Christensen, Trine Alma Knudsen and 6 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Christina Schjellerup Eickhardt-DalbøgeRegional Department of Clinical Microbiology, Zealand University Hospital , Koege, Denmark.ORCID 0000-0002-0740-0555
Anna Cäcilia InghamDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut , Copenhagen, Denmark.ORCID 0000-0001-6079-6643
Henrik V NielsenDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut , Copenhagen, Denmark.ORCID 0000-0002-6773-1874
Kurt FuurstedDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut , Copenhagen, Denmark.ORCID 0000-0002-3483-3145
Christen Rune StensvoldDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut , Copenhagen, Denmark.ORCID 0000-0002-1417-7048
Lee O'Brien AndersenDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut , Copenhagen, Denmark.ORCID 0009-0009-6266-6514
Morten Kranker LarsenDepartment of Hematology, Zealand University Hospital , Roskilde, Denmark.
Lasse KjærDepartment of Hematology, Zealand University Hospital , Roskilde, Denmark.ORCID 0000-0001-6767-0226
Sarah Friis ChristensenDepartment of Hematology, Zealand University Hospital , Roskilde, Denmark.ORCID 0000-0003-2178-0440
Trine Alma KnudsenDepartment of Hematology, Zealand University Hospital , Roskilde, Denmark.ORCID 0000-0001-9829-3099
Vibe SkovDepartment of Hematology, Zealand University Hospital , Roskilde, Denmark.ORCID 0000-0003-0097-7826
Christina EllervikFaculty of Health and Medical Sciences, University of Copenhagen , Copenhagen, Denmark.ORCID 0000-0002-3088-4375
Lars Rønn OlsenDepartment of Health Technology, Technical University of Denmark , Lyngby, Denmark.
Hans Carl Hasselbalch *Department of Hematology, Zealand University Hospital , Roskilde, Denmark.ORCID 0000-0003-3936-8032
Jens Jørgen Elmer Christensen *Regional Department of Clinical Microbiology, Zealand University Hospital , Koege, Denmark.ORCID 0000-0001-6721-4917
Xiaohui Chen Nielsen *Regional Department of Clinical Microbiology, Zealand University Hospital , Koege, Denmark.

Funding

The Danish Cancer SocietyThe Department of Bacteria, Parasites and Fungi, SSI, CopenhagenThe Region Zealand Foundation for health Research
6 · The paper itself

Abstract

importanceEssential thrombocythemia (ET) is a cancer characterized by thrombocyte overproduction. Inflammation has been shown to be vital in both the initiation and progression of other myeloproliferative neoplasms, and it is well known that the gut microbiota is important in the regulation of our immune system. However, the gut microbiota of patients with ET remains uninvestigated. In this study, we characterized the gut microbiota of patients with ET compared with healthy controls and thereby provide new insights into the field. We show that the gut microbiota of patients with ET differs significantly from that of healthy controls and the patients with ET have a lower relative abundance of important immunoregulative bacteria. Furthermore, we demonstrate that patients with

Indexed as

essential thrombocythemiaETgut microbiomegut microbiotainflammationJAK2V617Fmyelofibrosismyeloproliferative neoplasmspolycythemia vera

Identifiers

PMID37695126
PMCPMC10581245

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.