Evidence map›Paper›PMID 37695101›Full record

ArticleMicrobiology spectrum2023

Approaches for timeline reductions in pathogenesis studies using genetically modified mice.

Samantha Skavicus, Nicholas S Heaton

Abstract read
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. TheeLife · 2025
    Article
  3. ThebioRxiv : the preprint server for biology · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Samantha SkavicusDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine , Durham, North Carolina, USA.ORCID 0009-0003-1380-8551
Nicholas S HeatonDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine , Durham, North Carolina, USA.ORCID 0000-0002-5307-3428

Funding

Collaborative Influenza Vaccine Innovation Centers (CIVICs): Component A: Vaccine Center75N93019C00050 · NIAID · DUKE UNIVERSITY · PI MOODY, TONY · 2019 to 2025
$69.1M
Control of influenza virus induced type I interferon signaling during pregnancyR01AI168107 · NIAID · DUKE UNIVERSITY · PI Nicholas S Heaton · 2023 to 2026
$2.9M
DOD | Defense Advanced Research Projects Agency (DARPA) HR00111920008HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) R01-AI168107NIAID NIH HHS 75N93019C00050NIAID NIH HHS R01 AI168107
6 · The paper itself

Abstract

importanceClustered regularly interspaced short palindromic repeats (CRISPR)-based technologies have already begun to revolutionize biomedical science. An emerging application of this technology is in the development of genetically modified model organisms to study the mechanisms underlying infectious disease. Here, we describe a protocol using an

Indexed as

CRISPRIRF9knockout miceMx1transgenic mice

Identifiers

PMID37695101
PMCPMC10580824

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.