ArticleJournal of virology2023
PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner.
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Article in Journal of virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
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Who cites it
21 citing papers in PubMed, 23 citations in OpenAlex.
- Correlative Effects of PARP12 mRNA Knockdown on Pro-inflammatory Gene Expression and Alternative Splicing in BV2 Microglial Cells.Molecular neurobiology · 2026Article
- NADThe Journal of general virology · 2026Review
- An autoimmunity-associated allele ofProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo.Journal of medicinal chemistry · 2026Article
- Article
- An Autoimmunity-associated allele ofbioRxiv : the preprint server for biology · 2025Article
- Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy in vivo.bioRxiv : the preprint server for biology · 2025Article
- Macrodomain ADP-ribose binding but not ADP-ribosylhydrolase activity is critical for chikungunya virus infection ofbioRxiv : the preprint server for biology · 2025Article
- The Mac1 ADP-ribosylhydrolase is a Therapeutic Target for SARS-CoV-2.bioRxiv : the preprint server for biology · 2025Article
- Review
- Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle.Journal of virology · 2025Article
- Mono-ADP-ribosylating PARP enzymes in cellular signaling and disease.Journal of cell science · 2025Review
- PARP12-mediated mono-ADP-ribosylation as a checkpoint for necroptosis and apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Zinc-finger PARP proteins ADP-ribosylate alphaviral proteins and are required for interferon-γ-mediated antiviral immunity.Science advances · 2025Article
- PARP12-mediated ADP-ribosylation contributes to breast cancer cell fate by regulating AKT activation and DNA-damage response.Cellular and molecular life sciences : CMLS · 2025Article
- IFN-bioRxiv : the preprint server for biology · 2025Article
- IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice.PloS one · 2025Article
- Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for replication.Journal of virology · 2024Article
- Mutation of a highly conserved isoleucine residue in loop 2 of severalbioRxiv : the preprint server for biology · 2024Article
- PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon γ-induced ADP-ribosylation.The EMBO journal · 2024Article
Corrections and comments
- Update of
Authors and funding
9 authors at 2 institutions in 1 country.
Catherine M KerrDepartment of Molecular Biosciences, University of Kansas , Lawrence, Kansas, USA.
Srivatsan ParthasarathyDepartment of Molecular Biosciences, University of Kansas , Lawrence, Kansas, USA.
Nancy SchwartingDepartment of Molecular Biosciences, University of Kansas , Lawrence, Kansas, USA.
Joseph J O'ConnorDepartment of Molecular Biosciences, University of Kansas , Lawrence, Kansas, USA.
Jessica J PfannenstielDepartment of Molecular Biosciences, University of Kansas , Lawrence, Kansas, USA.
Emily GiriDepartment of Molecular Biosciences, University of Kansas , Lawrence, Kansas, USA.
Sunil MoreDepartment of Veterinary Pathology, Oklahoma State University , Stillwater, Oklahoma, USA.
Robin C OrozcoDepartment of Molecular Biosciences, University of Kansas , Lawrence, Kansas, USA.
Anthony R FehrDepartment of Molecular Biosciences, University of Kansas , Lawrence, Kansas, USA.ORCID 0000-0003-1560-1573
University of Kansas · USOklahoma State University · US
Funding
Transgenic & Gene-Targeting Shared ResourceP30CA168524 · NCI · UNIVERSITY OF KANSAS MEDICAL CENTER · PI NICOLE L NOLLEN · 2012 to 2026
$40.1MSynthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI KIM, HYUNJOON · 2016 to 2025
$23.9MGraduate Training at the Biology-Chemistry InterfaceT32GM132061 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Brian Douglas Ackley · 2020 to 2026
$2.9MDetermining mechanisms of innate immune modulation by ADP-ribosylationR35GM138029 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Anthony R Fehr · 2020 to 2026
$2.7MInvestigating How ADP-ribosylation Impacts Innate Immunity During Coronavirus InfectionK22AI134993 · NIAID · UNIVERSITY OF KANSAS LAWRENCE · PI FEHR, ANTHONY R · 2019 to 2020
$270kNCI NIH HHS P30 CA168524NIAID NIH HHS K22 AI134993NIGMS NIH HHS P20 GM113117NIGMS NIH HHS R35 GM138029NIGMS NIH HHS T32 GM132061
Abstract
ADP-ribosyltransferases (ARTs) mediate the transfer of ADP-ribose from NAD
Indexed as
Genes, ViralMurine hepatitis virusMutationPoly(ADP-ribose) PolymerasesVirus ReplicationAnimalsCell LineCoronavirus InfectionsDisease Models, AnimalInterferonsMiceMice, KnockoutOrgan SpecificityInterferonsPARP12 protein, mousePoly(ADP-ribose) PolymerasesADP-ribosylationcoronavirusmacrodomainMHVPARPpathology
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.