ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Delirium is associated with loss of feedback cortical connectivity.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Inflammation and delirium in critically Ill patients: a review.Frontiers in aging neuroscience · 2026Pooled it
- A novel index for trending sepsis and inflammatory response using processed EEG and Heart Rate Variability.Journal of clinical monitoring and computing · 2026Observational
- Peak alpha frequency and spectral exponent in postoperative delirium: a high-density EEG cohort study.BJA open · 2026Article
- Dysfunctional resting state network connectivity predicts postoperative delirium after major surgery.British journal of anaesthesia · 2026Article
- Can intraoperative electroencephalogram finally prevent emergence delirium in children?Translational pediatrics · 2026Article
- Predicting delirium in critically Ill COVID-19 patients using EEG-derived data: a machine learning approach.GeroScience · 2026Observational
- Preoperative Cholinergic Signatures Drive Segregated Brain Architecture in Postoperative Delirium.Research square · 2025Article
- Artificial intelligence in drug development for delirium and Alzheimer's disease.Acta pharmaceutica Sinica. B · 2025Review
- Article
- Solving the enigma of burst suppression.British journal of anaesthesia · 2025Article
- Relationship between preoperative high arterial blood lactate level and delirium after deep brain stimulation surgery in Parkinson's disease.Frontiers in aging · 2025Article
- Association of preoperative to postoperative change in cerebrospinal fluid fibrinogen with postoperative delirium.BJA open · 2024Article
- International Delirium Pathophysiology & Electrophysiology Network for Data sharing (iDEPEND).BJA open · 2024Article
- Delirium and Its Associations with Critical Care Utilizations and Outcomes at the Time of Hospital Discharge in Patients with Acute Brain Injury.Medicina (Kaunas, Lithuania) · 2024Article
- Delirium is associated with loss of feedback cortical connectivity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Neurophysiological patterns reflecting vulnerability to delirium subtypes: a resting-state EEG and event-related potential study.Brain communications · 2024Article
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8 authors.
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Abstract
introductionPost-operative delirium (POD) is associated with increased morbidity and mortality but is bereft of treatments, largely due to our limited understanding of the underlying pathophysiology. We hypothesized that delirium reflects a disturbance in cortical connectivity that leads to altered predictions of the sensory environment.
methodsHigh-density electroencephalogram recordings during an oddball auditory roving paradigm were collected from 131 patients. Dynamic causal modeling (DCM) analysis facilitated inference about the neuronal connectivity and inhibition-excitation dynamics underlying auditory-evoked responses.
resultsMismatch negativity amplitudes were smaller in patients with POD. DCM showed that delirium was associated with decreased left-sided superior temporal gyrus (l-STG) to auditory cortex feedback connectivity. Feedback connectivity also negatively correlated with delirium severity and systemic inflammation. Increased inhibition of l-STG, with consequent decreases in feed-forward and feed-back connectivity, occurred for oddball tones during delirium. DISCUSSION: Delirium is associated with decreased feedback cortical connectivity, possibly resulting from increased intrinsic inhibitory tone. HIGHLIGHTS: Mismatch negativity amplitude was reduced in patients with delirium. Patients with postoperative delirium had increased feedforward connectivity before surgery. Feedback connectivity was diminished from left-side superior temporal gyrus to left primary auditory sensory area during delirium. Feedback connectivity inversely correlated with inflammation and delirium severity.
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