Evidence map›Paper›PMID 37695011›Full record

ArticleThe Behavioral and brain sciences2023

Polygenic risk scores cannot make their mark on psychiatry without considering epigenetics.

Diane C Gooding, Anthony P Auger

Abstract readComment
PubMed Publisher
In one paragraph

Article in The Behavioral and brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Diane C GoodingDepartment of Psychology, University of Wisconsin-Madison, Madison, WI, USA dgooding@wisc.edu; https://drdianecgooding.com apauger@wisc.edu; https://augerlab.labs.wisc.edu.ORCID 0000-0002-0498-9472
Anthony P AugerDepartment of Psychology, University of Wisconsin-Madison, Madison, WI, USA dgooding@wisc.edu; https://drdianecgooding.com apauger@wisc.edu; https://augerlab.labs.wisc.edu.
University of Wisconsin–Madison · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We generally agree with Burt's thesis. However, we note that the author did not discuss epigenetics, the study of how the environment can alter gene structure and function. Given epigenetic mechanisms, the utility of polygenic risk scores (PRS) is limited in studies of development and mental illness. Finally, in this commentary we expand upon the risks of reliance upon PRSs.

Indexed as

Mental DisordersPsychiatryEpigenesis, GeneticHumansRisk Factors

Identifiers

PMID37695011
OpenAlexW4386592708

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.