ArticleThe Behavioral and brain sciences2023
Polygenic scores, and the genome-wide association studies they derive from, will have difficulty identifying genes that predispose one to develop a social behavioral trait.
Article in The Behavioral and brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Polygenic scores (PGSs) have several limitations. They are confounded with environmental effects on behavior and cannot be used to study how mutations affect brain function and behavior. For this, mutations with large effects, which often arise in only one geographical population are needed. Genome-wide association studies (GWASs), commonly used for identifying mutations, have difficulty detecting these mutations. A strategy that overcomes this challenge is discussed.
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