Evidence map›Paper›PMID 37694941›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2024

Skeletal Muscle Health, Physical Performance, and Lower Urinary Tract Symptoms in Older Adults: The Study of Muscle, Mobility, and Aging.

Scott R Bauer, Candace Parker-Autry, Kaiwei Lu, Steven R Cummings, Russell T Hepple, Rebecca Scherzer, Kenneth Covinsky, Peggy M Cawthon

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. What Is 'Muscle Health'? A Narrative Review and Conceptual Framework.Journal of functional morphology and kinesiology · 2025
    Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Scott R BauerDepartment of Medicine, University of California and the San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.ORCID 0000-0003-4908-1924
Candace Parker-AutryDepartment of Urology, Section on Female Pelvic Health, Wake Forest Baptist Health, Winston-Salem, North Carolina, USA.ORCID 0000-0002-4227-3600
Kaiwei LuDepartment of Urology, Section on Female Pelvic Health, Wake Forest Baptist Health, Winston-Salem, North Carolina, USA.
Steven R CummingsSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
Russell T HeppleDepartment of Physical Therapy, College of Public Health and Health Professions, University of Florida, Gainesville, Florida, USA.ORCID 0000-0003-3640-486X
Rebecca ScherzerDepartment of Medicine, University of California and the San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.
Kenneth CovinskyDepartment of Medicine, University of California and the San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.
Peggy M CawthonSan Francisco Coordinating Center, California Pacific Medical Center Research Institute, San Francisco, California, USA.
San Francisco VA Medical Center · USAtrium Health Wake Forest Baptist · USUniversity of California, San Francisco · USUniversity of Florida · US

Funding

Study of Muscle, Mobility and Aging: SOMMA2R01AG059416 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI STEVEN RON CUMMINGS, Peggy Mannen Cawthon · 2018 to 2026
$70.3M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 2013 to 2026
$19.9M
Age-related changes in skeletal muscle and lower urinary tract symptoms in older adultsK76AG074903 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BAUER, SCOTT RYAN · 2021 to 2025
$1.2M
Prescription exercise for Older men with Urinary Disease (PROUD) pilot studyR01DK135804 · NIDDK · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BAUER, SCOTT RYAN, KENFIELD, STACEY · 2023 to 2025
$1.0M
Longitudinal Associations Between Frailty and Lower Urinary Tract Symptoms in Older MenR03AG067937 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI BAUER, SCOTT RYAN · 2020 to 2021
$307k
NCATS NIH HHS UL1 0TR001420NIA NIH HHS 1R03AG067937NIA NIH HHS K76 AG074903NIA NIH HHS P30 AG021332NIA NIH HHS P30 AG024827NIA NIH HHS P30 AG044281NIA NIH HHS R01 AG059416NIA NIH HHS R03 AG067937NIDDK NIH HHS R01 DK135804
6 · The paper itself

Abstract

backgroundLower urinary tract symptoms (LUTS) and mobility limitations are bidirectionally associated among older adults, but the role of skeletal muscle remains unknown. We evaluated cross-sectional associations of muscle health and physical performance with LUTS.

methodsWe used data from 377 women and 264 men aged >70 years in the Study of Muscle, Mobility and Aging (SOMMA). LUTS and urinary bother were assessed using the LURN Symptom Index-10 (SI-10; higher = worse symptoms). Muscle mass and volume were assessed using D3-creatine dilution (D3Cr) and magnetic resonance imaging. Grip strength and peak leg power assessed upper/lower extremity physical performance. 400-m walk, Short Physical Performance Battery (SPPB), and Four Square Step Test (FSST) assessed global physical performance. Mobility Assessment Tool-short form (MAT-sf) assessed self-reported mobility. We calculated Spearman correlation coefficients adjusted for age, body mass index, multimorbidity, and polypharmacy, chi-square tests, and Fisher's Z-test to compare correlations.

resultsAmong women, LURN SI-10 total scores were inversely correlated with FSST (rs = 0.11, p = .045), grip strength (rs = -0.15, p = .006), and MAT-sf (rs = -0.18, p = .001), but not other muscle and physical performance measures in multivariable models. LURN SI-10 was not associated with any of these measures among men. Forty-four percent of women in the lowest tertile of 400-m walk speed versus 24% in the highest tertile reported they were at least "somewhat bothered" by urinary symptoms (p < .001), whereas differences among men were not significant.

conclusionsBalance and grip strength were associated with LUTS severity in older women but not men. Associations with other muscle and physical performance measures varied by LUTS subtype but remained strongest among women.

Indexed as

AgingLower Urinary Tract SymptomsMobility LimitationMuscle, SkeletalPhysical Functional PerformanceAgedAged, 80 and overCross-Sectional StudiesFemaleHand StrengthHumansMaleMuscle StrengthMobility limitationProstatic diseasesSarcopeniaUrinary bladder diseasesUrinary incontinence

Identifiers

PMID37694941
PMCPMC11083634
OpenAlexW4386592945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.