Evidence map›Paper›PMID 37694938›Full record

ArticleThe Behavioral and brain sciences2023

Extensions of the causal framework to Mendelian randomisation and gene-environment interaction.

Claire M A Haworth, Robyn E Wootton

Abstract readComment
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In one paragraph

Article in The Behavioral and brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Claire M A HaworthSchool of Psychological Science, University of Bristol, Bristol, UK claire.haworth@bristol.ac.ukhttps://www.bristol.ac.uk/people/person/Claire-Haworth-04ed5882-f1f6-4fb5-8960-5581b0cc8bc4/ robyn.wootton@bristol.ac.uk.ORCID 0000-0002-8608-289X
Robyn E WoottonSchool of Psychological Science, University of Bristol, Bristol, UK claire.haworth@bristol.ac.ukhttps://www.bristol.ac.uk/people/person/Claire-Haworth-04ed5882-f1f6-4fb5-8960-5581b0cc8bc4/ robyn.wootton@bristol.ac.uk.ORCID 0000-0003-3961-3202

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In our commentary we ask whether we should ultimately endeavour to find the deep causes of behaviours? Then we discuss two extensions of the proposed framework: (1) Mendelian randomisation and (2) hypothesis-free gene-environment interaction (leveraging heterogeneity in genetic associations). These complementary methods help move us towards second-generation causal knowledge, ultimately understanding mechanistic pathways and identifying more effective intervention targets.

Indexed as

Gene-Environment InteractionKnowledgeHumans

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.