ArticleThe Behavioral and brain sciences2023
The providential randomisation of genotypes.
Jean-Baptiste Pingault, Pasco Fearon, Essi Viding, Neil Davies, Marcus R Munafò, George Davey Smith
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In one paragraphArticle in The Behavioral and brain sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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1 · What the graph read from itWhat it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 0 citations in OpenAlex.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors at 3 institutions in 2 countries.
Jean-Baptiste PingaultDepartment of Clinical, Educational and Health Psychology, University College London, London, UK j.pingault@ucl.ac.uk www.jeanbaptistepingault.com p.fearon@ucl.ac.uk https://www.cfr.cam.ac.uk/staff/professor-pasco-fearon e.viding@ucl.ac.uk https://www.ucl.ac.uk/pals/people/essi-viding.ORCID 0000-0003-2557-4716 Pasco FearonDepartment of Clinical, Educational and Health Psychology, University College London, London, UK j.pingault@ucl.ac.uk www.jeanbaptistepingault.com p.fearon@ucl.ac.uk https://www.cfr.cam.ac.uk/staff/professor-pasco-fearon e.viding@ucl.ac.uk https://www.ucl.ac.uk/pals/people/essi-viding.
Essi VidingDepartment of Clinical, Educational and Health Psychology, University College London, London, UK j.pingault@ucl.ac.uk www.jeanbaptistepingault.com p.fearon@ucl.ac.uk https://www.cfr.cam.ac.uk/staff/professor-pasco-fearon e.viding@ucl.ac.uk https://www.ucl.ac.uk/pals/people/essi-viding.
Neil DaviesMedical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK Neil.Davies@bristol.ac.uk https://research-information.bris.ac.uk/en/persons/neil-m-davies marcus.munafo@bristol.ac.uk https://research-information.bris.ac.uk/en/persons/marcus-r-munafo KZ.Davey-Smith@bristol.ac.uk https://www.bristol.ac.uk/people/person/George-Davey%20Smith-285dce3f-4498-4e97-82de-250a865b4483/.
Marcus R MunafòMedical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK Neil.Davies@bristol.ac.uk https://research-information.bris.ac.uk/en/persons/neil-m-davies marcus.munafo@bristol.ac.uk https://research-information.bris.ac.uk/en/persons/marcus-r-munafo KZ.Davey-Smith@bristol.ac.uk https://www.bristol.ac.uk/people/person/George-Davey%20Smith-285dce3f-4498-4e97-82de-250a865b4483/.
George Davey SmithMedical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK Neil.Davies@bristol.ac.uk https://research-information.bris.ac.uk/en/persons/neil-m-davies marcus.munafo@bristol.ac.uk https://research-information.bris.ac.uk/en/persons/marcus-r-munafo KZ.Davey-Smith@bristol.ac.uk https://www.bristol.ac.uk/people/person/George-Davey%20Smith-285dce3f-4498-4e97-82de-250a865b4483/.
Department of Health and Social Care · GBBristol City Council · GBNorwegian University of Science and Technology · NO
Funding
Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00032/1Medical Research Council MC_UU_00032/7
6 · The paper itselfAbstract
When building causal knowledge in behavioural genetics, the natural randomisation of genotypes at conception (approximately analogous to the artificial randomisation occurring in randomised controlled trials) facilitates the discovery of genetic causes. More importantly, the randomisation of genetic material within families also enables a better identification of (environmental) risk factors and aetiological pathways to diseases and behaviours.
Indexed as
Genetics, BehavioralGenotypeHumansRandom Allocation
Identifiers
PMID37694914
OpenAlexW4386592215
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