Evidence map›Paper›PMID 37694568›Full record

ArticleNeurorehabilitation and neural repair2023

Effective Delivery of Vagus Nerve Stimulation Requires Many Stimulations Per Session and Many Sessions Per Week Over Many Weeks to Improve Recovery of Somatosensation.

Andrea D Ruiz, Kaitlyn M Malley, Tanya T Danaphongse, Fatima N Ahmad, Clareth Mota Beltran, Robert L Rennaker, Michael P Kilgard, Seth A Hays

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurorehabilitation and neural repair, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Andrea D RuizTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, USA.ORCID 0000-0002-3918-3882
Kaitlyn M MalleyTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, USA.
Tanya T DanaphongseTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, USA.
Fatima N AhmadTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, USA.
Clareth Mota BeltranTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, USA.
Robert L RennakerTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, USA.
Michael P KilgardTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, USA.
Seth A HaysTexas Biomedical Device Center, The University of Texas at Dallas, Richardson, TX, USA.
Texas Biomedical Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic sensory loss is a common and undertreated consequence of many forms of neurological injury. Emerging evidence indicates that vagus nerve stimulation (VNS) delivered during tactile rehabilitation promotes recovery of somatosensation.

objectiveHere, we characterize the amount, intensity, frequency, and duration of VNS therapy paradigms to determine the optimal dosage for VNS-dependent enhancement of recovery in a model of peripheral nerve injury (PNI).

methodsRats underwent transection of the medial and ulnar nerves in the forelimb, resulting in chronic sensory loss in the paw. Eight weeks after injury, rats were implanted with a VNS cuff and received tactile rehabilitation sessions consisting of repeated mechanical stimulation of the previously denervated forepaw paired with short bursts of VNS. Rats received VNS therapy in 1 of 6 systematically varied dosing schedules to identify a paradigm that balanced therapy effectiveness with a shorter regimen.

resultsDelivering 200 VNS pairings a day 4 days a week for 4 weeks produced the greatest percent improvement in somatosensory function compared to any of the 6 other groups (One Way analysis of variance at the end of therapy,

conclusionsOur findings demonstrate that an effective VNS therapy dosage delivers many stimulations per session, with many sessions per week, over many weeks. These results provide a framework to inform the development of VNS-based therapies for sensory restoration.

Indexed as

Peripheral Nerve InjuriesVagus Nerve StimulationAnimalsForelimbHandRatsUpper Extremitydosagemassed trainingnerve injuryneurorehabilitationspaced trainingvagal nerve stimulation

Identifiers

PMID37694568
PMCPMC10523825
OpenAlexW4386592206

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.