Evidence map›Paper›PMID 37694396›Full record

ArticleEpidemiology and infection2023

The correlation between humoral immune responses and severity of clinical symptoms in COVID-19 patients.

Shadi Akbarian, Mehdi Sheikhi, Parichehr Khedri, Narges Baharifar, Fatemeh Khalaf Shamsabadi, Mohammad Reza Davidi, Hossein Ali Khazaei, Hamidali Assarian, Abdolkarim Sheikhi

Abstract read
In one paragraph

Article in Epidemiology and infection, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shadi AkbarianDepartment of Microbiology, Borujerd Branch, Islamic Azad University, Borujerd, Iran.
Mehdi SheikhiFaculty of Medicine, Kazeroon Azad University, Kazeroon, Iran.
Parichehr KhedriDepartment of Microbiology, Borujerd Branch, Islamic Azad University, Borujerd, Iran.
Narges BaharifarDepartment of Immunology, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran.
Fatemeh Khalaf ShamsabadiDepartment of Microbiology, Borujerd Branch, Islamic Azad University, Borujerd, Iran.
Mohammad Reza DavidiFaculty of Medicine, Kazeroon Azad University, Kazeroon, Iran.
Hossein Ali KhazaeiDepartment of Immunology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.
Hamidali AssarianDepartment of Microbiology, Dr. Assarian Pathobiology Lab, Dezful, Iran.
Abdolkarim SheikhiDepartment of Immunology, Faculty of Medicine, Dezful University of Medical Sciences, Dezful, Iran.ORCID 0000-0002-3559-5548

Funding

Dezful University of Medical Science
6 · The paper itself

Abstract

The SARS-CoV-2 pandemic persists with global repercussions. Initial COVID-19 symptoms encompass pneumonia, fever, myalgia, and fatigue. The human immune system produces IgM and IgG antibodies in response to SARS-CoV-2. Despite previous research, a comprehensive understanding of the interplay between clinical manifestations and humoral immune responses remains elusive. This study aims to scrutinize this association. 134 COVID-19 patients were enrolled, and stratified into mild, moderate, and severe symptom groups. Serum IgM and IgG levels were assessed thrice at one-month intervals using ELISA. The findings reveal significant elevation in serum IgG levels in moderate compared to mild cases (

Indexed as

Antibodies, ViralCOVID-19Immunity, HumoralAdultAgedFemaleHumansImmunoglobulin GImmunoglobulin MMaleMiddle AgedSARS-CoV-2Severity of Illness IndexAntibodies, ViralImmunoglobulin GImmunoglobulin Mclinical symptomsCOVID-19IgGIgMimmune system

Identifiers

PMID37694396
PMCPMC10548535

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.