ArticleJournal of Alzheimer's disease : JAD2023
The Mediating Roles of Neurobiomarkers in the Relationship Between Education and Late-Life Cognition.
Priscilla A Amofa-Ho, Ariana M Stickel, Ruijia Chen, Lindsay C Kobayashi, M Maria Glymour, Chloe W Eng, Alzheimer’s Disease Neuroimaging Initiative
Abstract read
In one paragraphArticle in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Priscilla A Amofa-HoDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Ariana M StickelDepartment of Psychology, San Diego State University, San Diego, CA, USA.
Ruijia ChenDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Lindsay C KobayashiCenter for Social Epidemiology and Population Health, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.
M Maria GlymourDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Chloe W EngDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Alzheimer’s Disease Neuroimaging Initiative
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MSDSU FUERTE: Recognition of Excellence in DEIA and Mentorship in support of Faculty SuccessU54CA267789 · NCI · SAN DIEGO STATE UNIVERSITY · PI Mark Brian Reed, Maria Luisa Zuniga de Nuncio · 2021 to 2026
$15.5MResearch Training in Non-Pharmacological Interventions for Cognition in Aging, MCI, and Alzheimer's DiseaseT32AG020499 · NIA · UNIVERSITY OF FLORIDA · PI MARSISKE, MICHAEL, SMITH, GLENN E. · 2003 to 2024
$3.7MClinical and Translational Predoctoral training in Alzheimers Disease and Related DementiasT32AG061892 · NIA · UNIVERSITY OF FLORIDA · PI PARAMITA CHAKRABARTY, JADA M LEWIS · 2018 to 2026
$1.8MRisk Factors for Alzheimer's Disease Among Latinos: Relationships Between Cardiovascular Disease Risk, Acculturation, Small Vessel Disease, and Alzheimer's BiomarkersK08AG075351 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ariana Stickel · 2022 to 2026
$770kConference on Advanced Psychometric Methods in Cognitive Aging ResearchR13AG030995 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MUNGAS, DAN M. · 2008 to 2022
$620kLifecourse Stressors and Social Disparities in Cognitive Aging: The Roles of Social Networks and Sleep DisturbanceK00AG068431 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEN, RUIJIA · 2021 to 2024
$330kEducation and cognitive resilience: what is the role of education characteristics in shaping an ability to maintain high levels of cognitive functioning after the onset of diseaseF31AG062114 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ENG, CHLOE W · 2020 to 2022
$94kNCI NIH HHS U54 CA267789NIA NIH HHS F31 AG062114NIA NIH HHS K00 AG068431NIA NIH HHS K08 AG075351NIA NIH HHS L30 AG074401NIA NIH HHS R13 AG030995NIA NIH HHS T32 AG020499NIA NIH HHS T32 AG061892NIA NIH HHS U01 AG024904
6 · The paper itselfAbstract
backgroundThe mediating roles of neuropathologies and neurovascular damage in the relationship between early-life education and later-life cognitive function are unknown.
objectiveTo examine whether Alzheimer's and neurovascular biomarkers mediate the relationships between education and cognitive functions.
methodsData were from 537 adults aged 55-94 in the Alzheimer's Disease Neuroimaging Initiative 3. We tested whether the relationships between education (continuous, years) and cognitive function (memory, executive functioning, and language composites) were mediated by neuroimaging biomarkers (hippocampal volumes, cortical gray matter volumes, meta-temporal tau PET standard uptake value ratio, and white matter hyperintensity volumes). Models were adjusted for age, race, sex/gender, cardiovascular history, body mass index, depression, and Apolipoprotein E-ɛ4 status.
resultsHippocampal volumes and white matter hyperintensities partially mediated the relationships between education and cognitive function across all domains (6.43% to 15.72% mediated). The direct effects of education on each cognitive domain were strong and statistically significant.
conclusionsCommonly measured neurobiomarkers only partially mediate the relationships between education and multi-domain cognitive function.
Indexed as
Alzheimer DiseaseCognitive DysfunctionWhite MatterBiomarkersBrainCognitionHumansMagnetic Resonance ImagingNeuropsychological TestsBiomarkersAlzheimer’s diseasebrain agingcognitive agingeducationhippocampustauwhite matter hyperintensities
Identifiers
PMID37694365
PMCPMC10578223
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