ArticleJournal of Alzheimer's disease : JAD2023
Delayed and More Variable Unimanual and Bimanual Finger Tapping in Alzheimer's Disease: Associations with Biomarkers and Applications for Classification.
Article in Journal of Alzheimer's disease : JAD, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- White matter microstructure and motor function in amnestic mild cognitive impairment and Alzheimer's dementia.Neuroimage. Reports · 2026Article
- Article
- Average performance and performance variability on a brief functional fine motor test reflect distinct behavioral constructs in aging.Frontiers in aging neuroscience · 2026Article
- Differences in Finger Dexterity in Patients With Mild and Moderate Alzheimer's Disease-A Study of Cognitive Function by Disease Severity.Brain and behavior · 2025Article
- Neuropsychological correlates of reduced self-awareness of functional competency in persons with subjective memory complaints, mild cognitive impairment, and early probable Alzheimer's dementia.Frontiers in neurology · 2025Article
- Cognition and movement in neurodegenerative disorders: a dynamic duo.Neural regeneration research · 2024Article
- Alzheimer's disease biomarker burden in primary motor cortices is associated with poorer dexterity performance.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Development of a smartphone screening test for preclinical Alzheimer's disease and validation across the dementia continuum.BMC neurology · 2024Article
- Classification of Mild Cognitive Impairment and Alzheimer's Disease Using Manual Motor Measures.Neuro-degenerative diseases · 2024Article
- Brief webcam test of hand movements predicts episodic memory, executive function, and working memory in a community sample of cognitively asymptomatic older adults.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Hand motor function of patients with early- and late-onset Alzheimer's disease and its relation to activities of daily living.Journal of Alzheimer's disease reportsArticle
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundDespite reports of gross motor problems in mild cognitive impairment (MCI) and Alzheimer's disease (AD), fine motor function has been relatively understudied.
objectiveWe examined if finger tapping is affected in AD, related to AD biomarkers, and able to classify MCI or AD.
methodsForty-seven cognitively normal, 27 amnestic MCI, and 26 AD subjects completed unimanual and bimanual computerized tapping tests. We tested 1) group differences in tapping with permutation models; 2) associations between tapping and biomarkers (PET amyloid-β, hippocampal volume, and APOEɛ4 alleles) with linear regression; and 3) the predictive value of tapping for group classification using machine learning.
resultsAD subjects had slower reaction time and larger speed variability than controls during all tapping conditions, except for dual tapping. MCI subjects performed worse than controls on reaction time and speed variability for dual and non-dominant hand tapping. Tapping speed and variability were related to hippocampal volume, but not to amyloid-β deposition or APOEɛ4 alleles. Random forest classification (overall accuracy = 70%) discriminated control and AD subjects, but poorly discriminated MCI from controls or AD.
conclusionsMCI and AD are linked to more variable finger tapping with slower reaction time. Associations between finger tapping and hippocampal volume, but not amyloidosis, suggest that tapping deficits are related to neuropathology that presents later during the disease. Considering that tapping performance is able to differentiate between control and AD subjects, it can offer a cost-efficient tool for augmenting existing AD biomarkers.
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