Evidence map›Paper›PMID 37693885›Full record

ReviewInternational journal of nanomedicine2023

Plant-Derived Exosome-Like Nanovesicles: Current Progress and Prospects.

Nai Mu, Jie Li, Li Zeng, Juan You, Rong Li, Anquan Qin, Xueping Liu, Fang Yan, Zheng Zhou

Abstract readReview
In one paragraph

Review in International journal of nanomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 150 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Polygonum cuspidatum Exosome-Like Nanovesicles Alleviate Hypoxic Pulmonary Hypertension by Stabilizing PON1 to Inhibit MAPK-Mediated PASMC Phenotypic Switching.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  8. Review
  9. Article
  10. Citrus limon-Derived Extracellular Vesicles Promote Hair Growth.Applied biochemistry and biotechnology · 2026
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nai Mu *Department of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan Province, People's Republic of China.ORCID 0009-0000-2115-3864
Jie Li *Center for Medicine Research and Translation, Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, People's Republic of China.
Li ZengDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, People's Republic of China.ORCID 0009-0000-9267-1589
Juan YouDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, People's Republic of China.ORCID 0009-0002-9330-1744
Rong LiDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, People's Republic of China.ORCID 0009-0005-0090-1903
Anquan QinDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, People's Republic of China.ORCID 0000-0002-4740-6476
Xueping LiuDepartment of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan Province, People's Republic of China.
Fang YanCenter for Medicine Research and Translation, Chengdu Fifth People's Hospital, Chengdu, Sichuan Province, People's Republic of China.ORCID 0000-0002-7783-4738
Zheng ZhouDepartment of Clinical Medicine, North Sichuan Medical College, Nanchong, Sichuan Province, People's Republic of China.ORCID 0009-0008-0693-9429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are small extracellular vesicles, ranging in size from 30-150nm, which can be derived from various types of cells. In recent years, mammalian-derived exosomes have been extensively studied and found to play a crucial role in regulating intercellular communication, thereby influencing the development and progression of numerous diseases. Traditional Chinese medicine has employed plant-based remedies for thousands of years, and an increasing body of evidence suggests that plant-derived exosome-like nanovesicles (PELNs) share similarities with mammalian-derived exosomes in terms of their structure and function. In this review, we provide an overview of recent advances in the study of PELNs and their potential implications for human health. Specifically, we summarize the roles of PELNs in respiratory, digestive, circulatory, and other diseases. Furthermore, we have extensively investigated the potential shortcomings and challenges in current research regarding the mechanism of action, safety, administration routes, isolation and extraction methods, characterization and identification techniques, as well as drug-loading capabilities. Based on these considerations, we propose recommendations for future research directions. Overall, our review highlights the potential of PELNs as a promising area of research, with broad implications for the treatment of human diseases. We anticipate continued interest in this area and hope that our summary of recent findings will stimulate further exploration into the implications of PELNs for human health.

Indexed as

ExosomesExtracellular VesiclesAnimalsCell CommunicationHumansMammalsMedicine, Chinese TraditionalPulmonary Circulationexosomesnanocarriersnanotherapeuticsplantsvesicles

Identifiers

PMID37693885
PMCPMC10492547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.