Evidence map›Paper›PMID 37693630›Full record

ArticlebioRxiv : the preprint server for biology2023

Hybrid Amyloid Quantum Dot Nanoassemblies to Probe Neuroinflammatory Damage.

Wesley Chiang, Jennifer M Urban, Francine Yanchik-Slade, Angela Stout, Bradley L Nilsson, Harris A Gelbard, Todd D Krauss

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Wesley ChiangDepartment of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, 14642.
Jennifer M UrbanDepartment of Chemistry, Rochester, New York 14627-0216, United States.
Francine Yanchik-SladeDepartment of Chemistry, Rochester, New York 14627-0216, United States.
Angela StoutCenter for Neurotherapeutics Discovery and Department of Neurology, University of Rochester Medical Center, Rochester, NY, 14642.
Bradley L NilssonDepartment of Chemistry, Rochester, New York 14627-0216, United States.
Harris A GelbardCenter for Neurotherapeutics Discovery and Department of Neurology, University of Rochester Medical Center, Rochester, NY, 14642.
Todd D KraussDepartment of Chemistry, Rochester, New York 14627-0216, United States.
University of Rochester Medical Center · USUniversity of Rochester · USRochester Precision Optics (United States) · US

Funding

Targeted Neuro Protection of HIV-1 Associated Neurologic DiseaseP01MH064570 · NIMH · UNIVERSITY OF ROCHESTER · PI GELBARD, HARRIS A · 2001 to 2014
$19.4M
Virology/Immunology CoreP30AI078498 · NIAID · UNIVERSITY OF ROCHESTER · PI DEWHURST, STEPHEN · 2008 to 2018
$14.6M
Training in Wellness and Resiliency at the University of Rochester Medical Center and College of Arts, Sciences & EngineeringT32GM135134 · NIGMS · UNIVERSITY OF ROCHESTER · PI Jeffrey J Hayes, Lynne E Maquat · 2020 to 2026
$2.9M
Novel Peptide/siRNA Nanoparticles for Treatment of Acute Lung InjuryR01HL138538 · NHLBI · UNIVERSITY OF ROCHESTER · PI DEAN, DAVID A, NILSSON, BRADLEY L. · 2017 to 2020
$2.2M
NIH Training Grant in the Chemistry-Biology InterfaceT32GM118283 · NIGMS · UNIVERSITY OF ROCHESTER · PI BREN, KARA L., FASAN, RUDI · 2017 to 2021
$850k
Nanocrystal Quantum Dot Biomimetics of SARS-CoV-2 to Interrogate Neutrophil-Mediated Neuroinflammation at the Blood-Brain BarrierR21NS128502 · NINDS · UNIVERSITY OF ROCHESTER · PI GELBARD, HARRIS A, KRAUSS, TODD D · 2022 to 2022
$424k
Matrix-Assisted Laser Desorption Ionization Time-of-Flight (MALDI-TOF/TOF) Mass SpectrometerS10OD030302 · OD · UNIVERSITY OF ROCHESTER · PI NILSSON, BRADLEY L. · 2021 to 2021
$304k
NHLBI NIH HHS R01 HL138538NIAID NIH HHS P30 AI078498NIGMS NIH HHS T32 GM118283NIGMS NIH HHS T32 GM135134NIH HHS S10 OD030302NIMH NIH HHS P01 MH064570NINDS NIH HHS R21 NS128502
6 · The paper itself

Abstract

Various oligomeric species of amyloid-beta have been proposed to play different immunogenic roles in the cellular pathology of Alzheimer's Disease. However, investigating the role of a homogenous single oligomeric species has been difficult due to highly dynamic oligomerization and fibril formation kinetics that convert between many species. Here we report the design and construction of a quantum dot mimetic for larger spherical oligomeric amyloid species as an "endogenously" fluorescent proxy for this cytotoxic species to investigate its role in inducing inflammatory and stress response states in neuronal and glial cell types.

Indexed as

Alzheimer’samyloidbiomimeticfluorescence microscopyneuronal imagingneurotoxic oligomersquantum dots

Identifiers

PMID37693630
PMCPMC10491264
OpenAlexW4386351803

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.