Evidence map›Paper›PMID 37693628›Full record

ArticlebioRxiv : the preprint server for biology2023

Tropomyosin 1 deficiency facilitates cell state transitions to enhance hemogenic endothelial cell specification during hematopoiesis.

Madison B Wilken, Gennadiy Fonar, Catriana Nations, Giulia Pavani, Victor Tsao, James Garifallou, Joanna Tober, Laura Bennett, Jean Ann Maguire, Alyssa Gagne and 6 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Madison B WilkenDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA.
Gennadiy FonarDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA.
Catriana NationsCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA.
Giulia PavaniCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA.
Victor TsaoDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA.
James GarifallouDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA.
Joanna ToberDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Laura BennettDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Jean Ann MaguireCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA.
Alyssa GagneCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA.
Nkemdilim OkoliDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA.
Paul GadueCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA.
Stella T ChouDivision of Hematology, Children's Hospital of Philadelphia, Philadelphia, PA.
Nancy A SpeckDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Deborah L FrenchCenter for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia, Philadelphia, PA.
Christopher S ThomDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA.
Children's Hospital of Philadelphia · USUniversity of Pennsylvania · US

Funding

Improving transfusion therapy for patients with sickle cell disease with pluripotent stem cell-derived red cellsU01HL134696 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI CHOU, STELLA T · 2016 to 2022
$8.3M
Biochemistry of Leukemia Virus Core-Binding FactorR01HL091724 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SPECK, NANCY · 2008 to 2024
$8.3M
PCTC Administrative Coordinating CenterU24HL134763 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI ALBRECHT, JENNIFER S., TERRIN, MICHAEL L · 2016 to 2022
$7.9M
T32 Institutional Pediatric ResearchT32HD043021 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI Joseph W. St. Geme · 2002 to 2026
$6.4M
Graduate Training in Developmental BiologyT32HD083185 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Michael Granato, Foteini Mourkioti · 2015 to 2026
$4.0M
Repressing TGFbeta family signaling to promote hematopoietic stem cell formation in the embryoR01HL163265 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SPECK, NANCY · 2022 to 2024
$1.0M
Determining genetic mechanisms that drive in vitro hematopoiesisK99HL156052 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI THOM, CHRISTOPHER STEPHEN · 2021 to 2024
$670k
NHLBI NIH HHS K99 HL156052NHLBI NIH HHS R01 HL091724NHLBI NIH HHS R01 HL163265NHLBI NIH HHS U01 HL134696NHLBI NIH HHS U24 HL134763NICHD NIH HHS T32 HD043021NICHD NIH HHS T32 HD083185
6 · The paper itself

Abstract

Tropomyosins coat actin filaments and impact actin-related signaling and cell morphogenesis. Genome-wide association studies have linked

Indexed as

hematopoiesishemogenic endotheliumiPSCTropomyosin 1

Identifiers

PMID37693628
PMCPMC10491315
OpenAlexW4386401480

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.