Evidence map›Paper›PMID 37693622›Full record

ArticlebioRxiv : the preprint server for biology2024

Linda Zhang, Joanne I Hsu, Etienne D Braekeleer, Chun-Wei Chen, Tajhal D Patel, Alejandra G Martell, Anna G Guzman, Katharina Wohlan, Sarah M Waldvogel, Hidetaka Urya and 14 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Updated by
    2024
5 · Who and what money

Authors and funding

24 authors at 5 institutions in 4 countries.

Linda ZhangTranslational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-5777-2357
Joanne I HsuTranslational Biology and Molecular Medicine Graduate Program, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-1194-0650
Etienne D BraekeleerDepartment of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge.ORCID 0000-0003-4659-023X
Chun-Wei ChenStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.ORCID 0000-0001-6761-3002
Tajhal D PatelTexas Children's Hospital Department of Hematology/Oncology, Baylor College of Medicine, Houston, TX.
Alejandra G MartellDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Anna G GuzmanDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
Katharina WohlanDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-9147-4070
Sarah M WaldvogelMedical Scientist Training Program, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-3657-1951
Hidetaka UryaDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.
Ayala TovyStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.
Elsa CallenLaboratory of Genome Integrity, National Cancer Institute, National Institute of Health, Bethesda, MD.
Rebecca MurdaughStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.
Rosemary RichardStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.
Sandra JansenDonders Centre for Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0001-9453-8124
Lisenka VissersDonders Centre for Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0001-6470-5497
Bert B A de VriesDonders Centre for Neuroscience, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0002-2789-2120
Andre NussenzweigCancer and Cell Biology Graduate Program, Baylor College of Medicine, Houston, TX.
Shixia HuangDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.ORCID 0000-0003-2878-4129
Cristian CoarfaDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX.ORCID 0000-0002-4183-4939
Jamie N AnastasStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.ORCID 0000-0002-5317-5352
Koichi TakahashiDepartment of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX.ORCID 0000-0002-8027-9659
George VassiliouDepartment of Haematology, Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge.ORCID 0000-0003-4337-8022
Margaret A GoodellStem Cells and Regenerative Medicine Center, Baylor College of Medicine, Houston TX.ORCID 0000-0003-1111-2932
Baylor College of Medicine · USRadboud University Nijmegen · NLThe University of Texas MD Anderson Cancer Center · USWellcome/MRC Cambridge Stem Cell Institute · GBNational Cancer Institute · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI DAVID R ROWLEY · 2007 to 2026
$73.9M
Project 3: Contribution of inflammation and DNA damaging factors to clonal expansion and malignant transformation in a community cohort of older adultsP01CA265748 · NCI · BAYLOR COLLEGE OF MEDICINE · PI ELIZABETH A. PLATZ · 2022 to 2026
$13.6M
PPM1D in Clonal Hematopoiesis and MalignanciesR01CA237291 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MARGARET A. GOODELL, Koichi Takahashi · 2019 to 2026
$3.7M
MECHANISMS OF POL II ELONGATION IN DIFFUSE MIDLINE GLIOMAR01NS129860 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Jamie N. Anastas · 2023 to 2026
$1.8M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
Quanterix 2470 Arrayer for Reverse Phase Protein Array TechnologyS10OD028648 · OD · BAYLOR COLLEGE OF MEDICINE · PI HUANG, SHIXIA · 2020 to 2020
$300k
Cancer Research UK 23015NCI NIH HHS P01 CA265748NCI NIH HHS P30 CA125123NCI NIH HHS R01 CA237291NCRR NIH HHS S10 RR024574NIH HHS S10 OD028648NINDS NIH HHS R01 NS129860
6 · The paper itself

Abstract

The DNA damage response is critical for maintaining genome integrity and is commonly disrupted in the development of cancer. PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D) is a master negative regulator of the response; gain-of-function mutations and amplifications of

Identifiers

PMID37693622
PMCPMC10491179
OpenAlexW4386351587

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.