Evidence map›Paper›PMID 37693611›Full record

ArticlebioRxiv : the preprint server for biology2023

Natural genetic variation quantitatively regulates heart rate and dimension.

Jakob Gierten, Bettina Welz, Tomas Fitzgerald, Thomas Thumberger, Oliver Hummel, Adrien Leger, Philipp Weber, David Hassel, Norbert Hübner, Ewan Birney and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Jakob GiertenCentre for Organismal Studies (COS), Heidelberg University; Heidelberg, 69120, Germany.ORCID 0000-0001-8143-1918
Bettina WelzCentre for Organismal Studies (COS), Heidelberg University; Heidelberg, 69120, Germany.ORCID 0000-0002-5505-0588
Tomas FitzgeraldEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI); Cambridge, CB10 1SD, UK.ORCID 0000-0002-2370-8496
Thomas ThumbergerCentre for Organismal Studies (COS), Heidelberg University; Heidelberg, 69120, Germany.ORCID 0000-0001-8485-457X
Oliver HummelMax Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC); Berlin, 13125, Germany.
Adrien LegerEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI); Cambridge, CB10 1SD, UK.
Philipp WeberDepartment of Cardiology, Heidelberg University Hospital; Heidelberg, 69120, Germany.
David HasselGerman Centre for Cardiovascular Research (DZHK); Partner Site Heidelberg/Mannheim, Germany.
Norbert HübnerMax Delbruck Center for Molecular Medicine in the Helmholtz Association (MDC); Berlin, 13125, Germany.
Ewan BirneyEuropean Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI); Cambridge, CB10 1SD, UK.ORCID 0000-0001-8314-8497
Joachim WittbrodtCentre for Organismal Studies (COS), Heidelberg University; Heidelberg, 69120, Germany.ORCID 0000-0001-8550-7377
Heidelberg University · DEEuropean Bioinformatics Institute · GBMax Delbrück Center · DE

Funding

The medaka Kiyosu panel: dissecting GxE effects of environmental chemicalsR01ES029917 · NIEHS · EUROPEAN MOLECULAR BIOLOGY LABORATORY · PI BIRNEY, EWAN, GOLDSTONE, JARED VERRILL · 2019 to 2023
$2.1M
NIEHS NIH HHS R01 ES029917
6 · The paper itself

Abstract

The polygenic contribution to heart development and function along the health-disease continuum remains unresolved. To gain insight into the genetic basis of quantitative cardiac phenotypes, we utilize highly inbred Japanese rice fish models,

Identifiers

PMID37693611
PMCPMC10491305
OpenAlexW4386388198

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.