Evidence map›Paper›PMID 37693540›Full record

ArticlebioRxiv : the preprint server for biology2023

A subclass of evening cells promotes the switch from arousal to sleep at dusk.

Matthew P Brown, Shubha Verma, Isabelle Palmer, Adler Guerrero Zuniga, Clark Rosensweig, Mehmet F Keles, Mark N Wu

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Matthew P BrownSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, U.S.A.
Shubha VermaDepartment of Neurology, Johns Hopkins University, Baltimore, MD 21205, U.S.A.
Isabelle PalmerDepartment of Neurology, Johns Hopkins University, Baltimore, MD 21205, U.S.A.
Adler Guerrero ZunigaDepartment of Neurology, Johns Hopkins University, Baltimore, MD 21205, U.S.A.
Clark RosensweigDepartment of Neurobiology, Northwestern University, Evanston, IL 60201, U.S.A.
Mehmet F KelesDepartment of Neurology, Johns Hopkins University, Baltimore, MD 21205, U.S.A.
Mark N WuSolomon H. Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, U.S.A.
Johns Hopkins University · USNorthwestern University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Cale Whitworth · 2014 to 2026
$13.5M
Cross-Species Analyses of the Molecular and Circuit Basis ofSleepR35NS122181 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Mark N Wu · 2021 to 2026
$6.9M
Biochemistry, Cellular and Molecular Biology Program: JHU BioGREAT (Biomedical Graduate REsiliency & Adaptability Training)T32GM144272 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Takanari Inoue · 2022 to 2026
$5.4M
Genetic Analysis of Sleep RegulationR01NS079584 · NINDS · JOHNS HOPKINS UNIVERSITY · PI WU, MARK N · 2012 to 2020
$3.2M
Identification of Biomarkers Reflecting Homeostatic Sleep DriveF32NS110183 · NINDS · NORTHWESTERN UNIVERSITY · PI ROSENSWEIG, CLARK JEFFREY · 2018 to 2021
$158k
Functional and Developmental Analysis of Sleep Drive CircuitryF31NS117175 · NINDS · JOHNS HOPKINS UNIVERSITY · PI BROWN, MATTHEW PHILIP · 2020 to 2022
$138k
NIGMS NIH HHS T32 GM144272NIH HHS P40 OD018537NINDS NIH HHS F31 NS117175NINDS NIH HHS F32 NS110183NINDS NIH HHS R01 NS079584NINDS NIH HHS R35 NS122181
6 · The paper itself

Abstract

Animals exhibit rhythmic patterns of behavior that are shaped by an internal circadian clock and the external environment. While light intensity varies across the day, there are particularly robust differences at twilight (dawn/dusk). These periods are also associated with major changes in behavioral states, such as the transition from arousal to sleep. However, the neural mechanisms by which time and environmental conditions promote these behavioral transitions are poorly defined. Here, we show that the E1 subclass of

Indexed as

circadianDrosophilaevening cellssleep

Identifiers

PMID37693540
PMCPMC10491161
OpenAlexW4386243541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.