ArticlemedRxiv : the preprint server for health sciences2023
Association of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's Disease Sequencing Project.
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In one paragraph
Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed, 11 citations in OpenAlex.
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Authors and funding
33 authors at 11 institutions in 2 countries.
Wan-Ping LeeDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Seung Hoan ChoiDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Margaret G SheaBiostatistics and Epidemiology Data Analytics Center, Boston University School of Public Health, Boston, MA, USA.
Po-Liang ChengDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Beth A DombroskiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Achilleas N PitsillidesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Nancy L Heard-CostaDepartment of Neurology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA.
Hui WangDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Katia BulekovaResearch Computing Services, Information Services & Technology, Boston University, Boston, MA, USA.
Amanda B KuzmaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Yuk Yee LeungDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
John J FarrellBiomedical Genetics, Department of Medicine, Boston University Medical School, Boston, MA, USA.
Honghuang LinDepartment of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Adam NajDepartment of Biostatistics, Epidemiology, and Informatics, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Elizabeth E BlueDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.
Frederick NusetorDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Dongyu WangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Eric BoerwinkleDepartment of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
William S BushCleveland Institute for Computational Biology, Cleveland, OH, USA.
Xiaoling ZhangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Philip L De JagerCenter for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA.
Josée DupuisDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Lindsay A FarrerDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.
Eden MartinJohn P Hussman Institute for Human Genomics, Miami, FL, USA.
Margaret Pericak-VanceJohn P Hussman Institute for Human Genomics, Miami, FL, USA.
Sudha SeshadriGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, TX, USA.
Ellen M WijsmanDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.
Li-San WangDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Gerard D SchellenbergDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Anita L DestefanoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Jonathan L HainesCleveland Institute for Computational Biology, Cleveland, OH, USA.
Gina M PelosoDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Boston University · USUniversity of Pennsylvania · USCase Western Reserve University · USUniversity of Miami · USBaylor College of Medicine · USBrown Foundation · USColumbia University Irving Medical Center · USThe University of Texas Health Science Center at San Antonio · USUniversity of Massachusetts Chan Medical School · USUniversity of Washington · USUniversity of Washington Medical Center · US
Funding
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4MTBDU19AG068753 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ting Fang Alvin Ang · 2020 to 2026
$42.4MTHE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITEU24AG041689 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LI-SAN WANG · 2012 to 2026
$42.3MWhole Genome Sequencing in Ethnically Diverse Cohorts for the ADSP Follow-Up Study (FUS)U01AG057659 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MAYEUX, RICHARD P, PERICAK-VANCE, MARGARET A. · 2017 to 2021
$34.4MGenome Center for Alzheimer's Disease (GCAD)U54AG052427 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID, WANG, LI-SAN · 2016 to 2025
$32.8MUniversity of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Amanda D. Boyd · 2020 to 2026
$29.0MThe Origins of Alzheimer Disease in African AmericansR01AG072547 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Rufus Olusola Akinyemi, GOLDIE S. BYRD · 2022 to 2026
$26.1MRL5: Research Education CoreP30AG072978 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ann C. McKee · 2021 to 2026
$25.6MResearch Education ComponentP30AG072979 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVID A WOLK · 2021 to 2026
$24.8MThe Alzheimer Disease Sequence Analysis CollaborativeU01AG058654 · NIA · CASE WESTERN RESERVE UNIVERSITY · PI BUSH, WILLIAM S, FARRER, LINDSAY A. · 2018 to 2022
$14.6MGenomic Characterization of Alzheimer Disease Risk in Admixed Populations with Native American and Southern European Genetic AncestryR01AG070864 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Margaret A. Pericak-Vance, FARID RAJABLI · 2021 to 2026
$12.1MTherapeutic target discovery in ADSP data via comprehensive whole-genome analysis incorporating ethnic diversity and systems approachesU01AG058589 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOERWINKLE, ERIC A., DE JAGER, PHILIP L · 2018 to 2022
$11.1MNHLBI NIH HHS R01 HL105756NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG072978NIA NIH HHS P30 AG072979NIA NIH HHS R01 AG048927NIA NIH HHS R01 AG070864NIA NIH HHS R01 AG072547NIA NIH HHS R01 AG080810NIA NIH HHS RF1 AG074328NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG057659NIA NIH HHS U01 AG058589NIA NIH HHS U01 AG058654NIA NIH HHS U01 AG062602NIA NIH HHS U01 AG062943NIA NIH HHS U01 AG068221NIA NIH HHS U01 AG072577NIA NIH HHS U19 AG068753NIA NIH HHS U24 AG041689NIA NIH HHS U54 AG052427
Abstract
Alzheimer's Disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous. Here, we investigated the association between AD and both common variants and aggregates of rare coding and noncoding variants in 13,371 individuals of diverse ancestry with whole genome sequence (WGS) data. Pooled-population analyses identified genetic variants in or near
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