Evidence map›Paper›PMID 37693488›Full record

ArticlebioRxiv : the preprint server for biology2023

Common as well as unique methylation-sensitive DNA regulatory elements in three mammalian SLC9C1 genes.

Cameron C Gardner, Jason A Abele, Thomas J Winkler, Caroline N Reckers, Sydney A Anas, Paul F James

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cameron C Gardner
Jason A Abele
Thomas J Winkler
Caroline N Reckers
Sydney A Anas
Paul F James
Miami University · US

Funding

Determining the role of DNA methylation in the tissue-specific expression of the Na,K-ATPase-Na/H exchanger pH regulatory system genes.R15HD101985 · NICHD · MIAMI UNIVERSITY OXFORD · PI JAMES, PAUL F · 2021 to 2021
$423k
NICHD NIH HHS R15 HD101985
6 · The paper itself

Abstract

The SLC9C1 gene (which encodes the NHE10 protein) is essential for male fertility in both mice and humans, however the epigenetic mechanisms regulating its testis/sperm-specific gene expression have yet to be studied. Here we identify and characterize DNA regulatory elements of the SLC9C1 gene across three mammalian species: mouse, rat, and human. First,

Indexed as

CpG IslandDNA methylationEpigeneticsNa+/H+ Exchangers (NHEs)NHE10 (sNHE)SLC9C1

Identifiers

PMID37693488
PMCPMC10491193
OpenAlexW4386294242

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.