Evidence map›Paper›PMID 37693481›Full record

ArticleResearch square2023

Computational Peptide Discovery with a Genetic Programming Approach.

Nicolas Scalzitti, Iliya Miralavy, David E Korenchan, Christian T Farrar, Assaf A Gilad, Wolfgang Banzhaf

Abstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Nicolas ScalzittiBEACON Center of Evolution in Action, Michigan State University, East Lansing, MI, USA.
Iliya MiralavyBEACON Center of Evolution in Action, Michigan State University, East Lansing, MI, USA.
David E KorenchanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Christian T FarrarAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Assaf A GiladBEACON Center of Evolution in Action, Michigan State University, East Lansing, MI, USA.
Wolfgang BanzhafBEACON Center of Evolution in Action, Michigan State University, East Lansing, MI, USA.

Funding

Clinically Translatable MRI Reporter Genes and Imaging Methods with Ultra-High Specificity and SensitivityR01EB031008 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTIAN T FARRAR · 2021 to 2026
$4.0M
Evolution and optimization of synthetic <READ/WRITE> function from and into cells using genetic programmingR01EB030565 · NIBIB · MICHIGAN STATE UNIVERSITY · PI BANZHAF, WOLFGANG, GILAD, ASSAF A · 2021 to 2024
$2.3M
Semi-synthetic, magneto-photonic circuit for non-invasive control of cellular functionR01EB031936 · NIBIB · CENTRAL MICHIGAN UNIVERSITY · PI GILAD, ASSAF A, HOCHGESCHWENDER, UTE H · 2021 to 2021
$2.0M
Molecular Imaging for Detection of Synthetic Biology Circuits, Oscillators and Toggle Switches in Regenerative MedicineR01NS104306 · NINDS · MICHIGAN STATE UNIVERSITY · PI GILAD, ASSAF A · 2018 to 2021
$1.3M
Upgrade of Console for 600 MHz MR SpectrometerS10OD023406 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CHENG, LEO L · 2017 to 2017
$600k
NIBIB NIH HHS R01 EB030565NIBIB NIH HHS R01 EB031008NIBIB NIH HHS R01 EB031936NIH HHS S10 OD023406NINDS NIH HHS R01 NS104306
6 · The paper itself

Abstract

Background: The development of peptides for therapeutic targets or biomarkers for disease diagnosis is a challenging task in protein engineering. Current approaches are tedious, often time-consuming and require complex laboratory data due to the vast search space. Results: This study presents the development and use of a variant of the initial POET algorithm, called Conclusions: By combining the power of genetic programming with the flexibility of regular expressions, new potential peptide targets were identified to improve the sensitivity of detection by CEST. This approach provides a promising research direction for the efficient identification of peptides with therapeutic or diagnostic potential.

Indexed as

CEST MRIcontrast agentEvolutionary algorithmGenetic programmingPeptide discoveryregular expressions

Identifiers

PMID37693481
PMCPMC10491332

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.