Evidence map›Paper›PMID 37693417›Full record

ArticlebioRxiv : the preprint server for biology2023

Mechanisms used for cDNA synthesis and site-specific integration of RNA into DNA genomes by a reverse transcriptase-Cas1 fusion protein.

Georg Mohr, Jun Yao, Seung Kuk Park, Laura M Markham, Alan M Lambowitz

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Georg MohrDepartments of Molecular Biosciences and Oncology University of Texas at Austin Austin TX, 78712.
Jun YaoDepartments of Molecular Biosciences and Oncology University of Texas at Austin Austin TX, 78712.
Seung Kuk ParkDepartments of Molecular Biosciences and Oncology University of Texas at Austin Austin TX, 78712.
Laura M MarkhamDepartments of Molecular Biosciences and Oncology University of Texas at Austin Austin TX, 78712.
Alan M LambowitzDepartments of Molecular Biosciences and Oncology University of Texas at Austin Austin TX, 78712.
The University of Texas at Austin · US

Funding

Group II Intron and Related Reverse TranscriptasesR35GM136216 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI ALAN M. LAMBOWITZ · 2020 to 2026
$6.0M
NIGMS NIH HHS R35 GM136216
6 · The paper itself

Abstract

Reverse transcriptase-Cas1 (RT-Cas1) fusion proteins found in some CRISPR systems enable spacer acquisition from both RNA and DNA, but the mechanism of RNA spacer acquisition has remained unclear. Here, we found

Indexed as

genome engineeringprime editingsite-specific DNA integrationspacer acquisition

Identifiers

PMID37693417
PMCPMC10491204
OpenAlexW4386399796

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.