Evidence map›Paper›PMID 37693415›Full record

ArticlebioRxiv : the preprint server for biology2023

SARS-CoV-2 hijacks fragile X mental retardation proteins for efficient infection.

Dimitriya H Garvanska, Rojelio E Alvarado, Filip Oskar Mundt, Emma Nilsson, Josephine Kerzel Duel, Fabian Coscia, Richard Lindqvist, Kumari Lokugamage, Bryan A Johnson, Jessica A Plante and 14 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 3 institutions in 3 countries.

Dimitriya H GarvanskaNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Rojelio E AlvaradoDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Filip Oskar MundtNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Emma NilssonDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Josephine Kerzel DuelNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Fabian CosciaNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Richard LindqvistDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Kumari LokugamageDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Bryan A JohnsonDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Jessica A PlanteDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Dorothea R MorrisDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Michelle N VuDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Leah K EstesDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Alyssa M McLelandDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Jordyn WalkerDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Patricia A Crocquet-ValdesDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Blanca Lopez MendezNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Kenneth S PlanteDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
David H WalkerDepartment of Pathology, University of Texas Medical Branch, Galveston, TX, United States.
Melanie Bianca WeisserNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Anna K OverbyDepartment of Clinical Microbiology, Umeå University, Umeå, Sweden.
Matthias MannNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Vineet D MenacheryDepartment of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas, USA.
Jakob NilssonNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
The University of Texas Medical Branch at Galveston · USUniversity of Copenhagen · DKUmeå University · SE

Funding

Virology CoreU19AI171413 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI DIAGANA, THIERRY, MENACHERY, VINEET D · 2022 to 2023
$75.0M
World Reference Center for Emerging Viruses and Arboviruses (WRCEVA)R24AI120942 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI WEAVER, SCOTT C · 2016 to 2024
$8.5M
Biodefense Training ProgramT32AI060549 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ASHOK K CHOPRA, Janice J Endsley · 2004 to 2026
$3.0M
Identifying host and viral correlates for coronavirus pathogenesisR01AI153602 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI JOHNSON, BRYAN A · 2020 to 2023
$2.0M
The Host Genetics of Age-Dependent SusceptibilityR21AI145400 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI MENACHERY, VINEET D · 2020 to 2021
$451k
NIAID NIH HHS R01 AI153602NIAID NIH HHS R21 AI145400NIAID NIH HHS R24 AI120942NIAID NIH HHS T32 AI060549NIAID NIH HHS U19 AI171413
6 · The paper itself

Abstract

Viruses interact with numerous host factors to facilitate viral replication and to dampen antiviral defense mechanisms. We currently have a limited mechanistic understanding of how SARS-CoV-2 binds host factors and the functional role of these interactions. Here, we uncover a novel interaction between the viral NSP3 protein and the fragile X mental retardation proteins (FMRPs: FMR1 and FXR1-2). SARS-CoV-2 NSP3 mutant viruses preventing FMRP binding have attenuated replication

Identifiers

PMID37693415
PMCPMC10491247
OpenAlexW4386392380

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.