Evidence map›Paper›PMID 37693386›Full record

ArticleResearch square2023

Arfid Genes and Environment (ARFID-GEN): Study Protocol.

Cynthia M Bulik, Nadia Micali, Casey M MacDermod, Baiyu Qi, Melissa A Munn-Chernoff, Laura M Thornton, Jennifer White, Lisa Dinkler, Emily M Pisetsky, Jessica Johnson and 8 more

Registry-linked trialOpen access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05605067 (Genetic Architecture of Avoidant/Restrictive Food Intake Disorder), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05605067 completednot on this map

Genetic Architecture of Avoidant/Restrictive Food Intake Disorder

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2023 to 2024Enrolled5,076ConditionsARFID, Eating Disorders, Eating Disorders in Children, Eating, Picky
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 3 countries.

Cynthia M BulikUniversity of North Carolina at Chapel Hill.
Nadia MicaliMental Health Services of the Capital Region of Denmark.
Casey M MacDermodUniversity of North Carolina at Chapel Hill.
Baiyu QiUniversity of North Carolina at Chapel Hill.
Melissa A Munn-ChernoffUniversity of North Carolina at Chapel Hill.
Laura M ThorntonUniversity of North Carolina at Chapel Hill.
Jennifer WhiteUniversity of North Carolina at Chapel Hill.
Lisa DinklerKarolinska Institutet.
Emily M PisetskyUniversity of North Carolina at Chapel Hill.
Jessica JohnsonUniversity of North Carolina at Chapel Hill.
Katelin R DevineUniversity of North Carolina at Chapel Hill.
Shelby N OrtizUniversity of North Carolina at Chapel Hill.
Ava E SilvermanUniversity of North Carolina at Chapel Hill.
Natasha BertholdUniversity of North Carolina at Chapel Hill.
Alexis DumainUniversity of North Carolina at Chapel Hill.
Jerry GuintivanoUniversity of North Carolina at Chapel Hill.
Matthew HalvorsenUniversity of North Carolina at Chapel Hill.
J JamesUniversity of North Carolina at Chapel Hill.
University of North Carolina at Chapel Hill · USKarolinska Institutet · SEMental Health Services · DK

Funding

North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
1/7 PGC: Advancing Discovery and ImpactR01MH124871 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, SULLIVAN, PATRICK F · 2021 to 2025
$3.5M
Genetic Architecture of Avoidant/Restrictive Food Intake DisorderR56MH129437 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, MICALI, NADIA · 2022 to 2023
$1.5M
NCATS NIH HHS UL1 TR001111NIMH NIH HHS R01 MH124871NIMH NIH HHS R56 MH129437
6 · The paper itself

Abstract

Background: The Avoidant Restrictive Food Intake Disorder Genes and Environment (ARFID-GEN) study is a study of genetic and environmental factors that contribute to risk for developing ARFID in children and adults. Methods: A total of 3,000 children and adults with ARFID from the United States will be included. Parents/guardians and their children with ARFID (ages 7 to 17) and adults with ARFID (ages 18+) will complete comprehensive online consent, parent verification of child assent (when applicable), and phenotyping. Enrolled participants with ARFID will submit a saliva sample for genotyping. A genome-wide association study of ARFID will be conducted. Discussion: ARFID-GEN, a large-scale genetic study of ARFID, is designed to rapidly advance the study of the genetics of eating disorders. We will explicate the genetic architecture of ARFID relative to other eating disorders and to other psychiatric, neurodevelopmental, and metabolic disorders and traits. Our goal is for ARFID to deliver "actionable" findings that can be transformed into clinically meaningful insights. Trial registration: ARFID-GEN is a registered clinical trial: clinicaltrials.gov NCT05605067.

Indexed as

avoidant restrictive food intake disordereating disordersgenome-wide associationpicky eatingpsychiatric geneticspsychiatric genomics consortiumselective eatingsocial media

Identifiers

PMID37693386
PMCPMC10491341
OpenAlexW4386318689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.