Evidence map›Paper›PMID 37693385›Full record

ArticleResearch square2023

Benign breast disease and breast cancer risk in African women: A case-control study.

Olasubomi J Omoleye, Jincong Q Freeman, Mojisola Oluwasanu, Adenike Adeniji-Sofoluwe, Anna E Woodard, Benjamin S Aribisala, Prisca O Adejumo, Atara Ntekim, Timothy Makumbi, Paul Ndom and 3 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Olasubomi J OmoleyeUniversity of Chicago.
Jincong Q FreemanUniversity of Chicago.
Mojisola OluwasanuUniversity of Ibadan.
Adenike Adeniji-SofoluweUniversity of Ibadan.
Anna E WoodardUniversity of Chicago.
Benjamin S AribisalaLagos State University.
Prisca O AdejumoUniversity of Ibadan.
Atara NtekimUniversity of Ibadan.
Timothy MakumbiMulago Hospital.
Paul NdomHôpital Général Yaoundé.
IkeOluwapo O AjayiUniversity of Ibadan.
Olufunmilayo I OlopadeUniversity of Chicago.
Dezheng HuoUniversity of Chicago.
University of Chicago · USUniversity of Ibadan · NGLagos State University · NGMulago Hospital · UGYaoundé General Hospital · CM

Funding

Polygenic Risk Prediction of Breast Cancer for Women of African DescentR01CA228198 · NCI · UNIVERSITY OF CHICAGO · PI Dezheng Huo · 2018 to 2026
$3.9M
Using Genomics to Reduce Breast Cancer Disparities in the African DiasporaU01CA161032 · NCI · UNIVERSITY OF CHICAGO · PI HUO, DEZHENG, OLOPADE, OLUFUNMILAYO F. · 2012 to 2015
$3.6M
Etiology and Genomics of Breast Cancer Progression in Women of African AncestryR01MD013452 · NIMHD · UNIVERSITY OF CHICAGO · PI HUO, DEZHENG, OLOPADE, OLUFUNMILAYO F. · 2019 to 2023
$2.8M
Genetics of Breast Cancer in BlacksR01CA089085 · NCI · UNIVERSITY OF CHICAGO · PI OLOPADE, OLUFUNMILAYO F. · 2002 to 2006
$2.8M
NCI NIH HHS R01 CA089085NCI NIH HHS R01 CA228198NCI NIH HHS U01 CA161032NIMHD NIH HHS R01 MD013452
6 · The paper itself

Abstract

Purpose: To examine the association between benign breast disease (BBD) and breast cancer (BC) in a heterogeneous population of African women. Methods: BC cases and matched controls were enrolled in three sub-Saharan African countries, Nigeria Cameroon, and Uganda, between 1998-2018. Multivariable logistic regression was used to test the association between BBD and BC. Risk factors dually associated with BBD and BC were selected. Using a parametric mediation analysis model, we assessed if selected BC risk factors were mediated by BBD. Results: Of 6418 participants, 55.7% (3572) were breast cancer cases. 360 (5.7%) self-reported BBD. Fibroadenoma (46.8%) was the most reported BBD. Women with a self-reported history of BBD had greater odds of developing BC than those without (adjusted odds ratio [aOR] = 1.47, 95% CI: 1.13-1.91). Biopsy-confirmed BBD was associated with BC (aOR = 3.11, 95% CI: 1.78-5.44). BBD did not significantly mediate the effects of any of the selected BC risk factors. Conclusions: In this study, BBD was associated with BC and did not significantly mediate the effects of selected BC risk factors.

Indexed as

AfricaBenign breast diseaseBreast cancerNigeriaRisk factors

Identifiers

PMID37693385
PMCPMC10491333
OpenAlexW4386370219

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.