Evidence map›Paper›PMID 37693381›Full record

ArticlebioRxiv : the preprint server for biology2024

Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice.

Atsuki En, Hanumakumar Bogireddi, Briana Thomas, Alexis Stutzman, Sachie Ikegami, Brigitte LaForest, Omar Almakki, Peter Pytel, Ivan P Moskowitz, Kohta Ikegami

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Atsuki EnDivision of Molecular Cardvascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Hanumakumar BogireddiDivision of Molecular Cardvascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Briana ThomasDivision of Molecular Cardvascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Alexis StutzmanDepartment of Pediatrics, The University of Chicago, Chicago, IL, USA.
Sachie IkegamiDepartment of Pediatrics, The University of Chicago, Chicago, IL, USA.
Brigitte LaForestDepartment of Pediatrics, The University of Chicago, Chicago, IL, USA.
Omar AlmakkiDepartment of Pediatrics, The University of Chicago, Chicago, IL, USA.
Peter PytelDepartment of Pathology, The University of Chicago, Chicago, IL, USA.
Ivan P MoskowitzDepartment of Pediatrics, The University of Chicago, Chicago, IL, USA.
Kohta IkegamiDivision of Molecular Cardvascular Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
University of Chicago · USCincinnati Children's Hospital Medical Center · US

Funding

Genetic and Molecular Analysis of Mutants with Congenital Heart DefectsR01HL092153 · NHLBI · UNIVERSITY OF CHICAGO · PI MOSKOWITZ, IVAN PAUL · 2009 to 2017
$4.5M
Discovery and interrogation of genetic regulatory variation impacting Atrial Fibrillation riskR01HL163523 · NHLBI · UNIVERSITY OF CHICAGO · PI HE, XIN, MOSKOWITZ, IVAN PAUL · 2022 to 2025
$3.1M
Etiology of Congenital Heart Disease in Down SyndromeR01HL124836 · NHLBI · UNIVERSITY OF CHICAGO · PI MOSKOWITZ, IVAN PAUL, REEVES, ROGER H · 2014 to 2017
$2.7M
Gene Regulatory Networks for Cardiac MorphogenesisR01HL126509 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CONLON, FRANK LEO, CRISTEA, ILEANA M. · 2017 to 2020
$2.5M
Mechanisms in Lamin A function in gene regulationR33AG054770 · NIA · UNIVERSITY OF CHICAGO · PI IKEGAMI, KOHTA · 2019 to 2021
$1.6M
Mechanisms in Lamin A function in gene regulationR21AG054770 · NIA · UNIVERSITY OF CHICAGO · PI IKEGAMI, KOHTA · 2017 to 2018
$410k
NHLBI NIH HHS R01 HL092153NHLBI NIH HHS R01 HL124836NHLBI NIH HHS R01 HL126509NHLBI NIH HHS R01 HL163523NIA NIH HHS R33 AG054770
6 · The paper itself

Abstract

Nuclear envelope (NE) ruptures are emerging observations in Lamin-related dilated cardiomyopathy, an adult-onset disease caused by loss-of-function mutations in Lamin A/C, a nuclear lamina component. Here, we tested a prevailing hypothesis that NE ruptures trigger pathological cGAS-STING cytosolic DNA-sensing pathway, using a mouse model of Lamin-cardiomyopathy. Reduction of Lamin A/C in cardiomyocytes of adult mice caused pervasive NE ruptures in cardiomyocytes, preceding inflammatory transcription, fibrosis, and fatal dilated cardiomyopathy. NE ruptures were followed by DNA damage accumulation without causing immediate cardiomyocyte death. However, cGAS-STING-dependent inflammatory signaling remained inactive. Deleting

Identifiers

PMID37693381
PMCPMC10491116
OpenAlexW4386253375

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.