Evidence map›Paper›PMID 37693365›Full record

ArticleFrontiers in endocrinology2023

TOETVA parathyroid autofluorescence detection: hANDY-i endoscopy attachment.

Stefanie Seo, Khalid Mohamed Ali, Samantha A Wolfe, Nimesh V Nagururu, Andy S Ding, Dipan Desai, R Alex Harbison, Yoseph Kim, Bo Ning, Richard Jaepyeong Cha and 1 more

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In one paragraph

Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stefanie SeoDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Khalid Mohamed AliDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Samantha A WolfeDepartment of Endocrine Surgery, University Health Network, Toronto, ON, Canada.
Nimesh V NagururuDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Andy S DingDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Dipan DesaiDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.
R Alex HarbisonDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.
Yoseph KimDepartment of Research, Optosurgical, LLC, Columbia, MD, United States.
Bo NingSheikh Zayed Institute, Children's National Hospital, Washington, DC, United States.
Richard Jaepyeong ChaDepartment of Research, Optosurgical, LLC, Columbia, MD, United States.
Jonathon O RussellDepartment of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, United States.

Funding

hANDY-i(TM): A non-invasive, dual-sensor handheld imager for intraoperative preservation of parathyroid glandsR44EB030874 · NIBIB · OPTOSURGICAL, LLC · PI CHA, RICHARD JAEPYEONG, OH, EUGENE · 2022 to 2023
$1.7M
NIBIB NIH HHS R44 EB030874
6 · The paper itself

Abstract

Background: Treatment options for thyroid pathologies have expanded to include scarless and remote access methods such as the transoral endoscopic thyroidectomy vestibular approach (TOETVA). Currently, no standardized methods exist for locating parathyroid glands (PGs) in patients undergoing TOETVA, which can lead to parathyroid injury and subsequent hypocalcemia. This early feasibility study describes and evaluates the hANDY-i endoscopic attachment for detecting PGs in transoral thyroidectomy. Methods: We used a prototype parathyroid autofluorescence imager (hANDY-i) that was mounted to a 10-mm 0-degree endoscope. The device delivers a split screen view of Red-green-blue (RGB) and near-infrared autofluorescence (NIRAF) which allows for simultaneous anatomical localization and fluorescence visualization of PGs during endoscopic thyroid dissection. Results: One cadaveric case and two patient cases were included in this study. The endoscopic hANDY-i imaging system successfully visualized PGs during all procedures. Conclusion: The ability to leverage parathyroid autofluorescence during TOETVA may lead to improved PG localization and preservation. Further human studies are needed to assess its effect on postoperative hypocalcemia and hypoparathyroidism.

Indexed as

HypocalcemiaThyroidectomyEndoscopy, GastrointestinalHumansParathyroid GlandsThyroid Glandendoscopynear-infrared autofluorescenceparathyroid glandsremote-access thyroidectomythyroidectomy

Identifiers

PMID37693365
PMCPMC10484600

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.