Evidence map›Paper›PMID 37693260›Full record

ArticleJournal of clinical and experimental hepatology

CT Texture Analysis in Nonalcoholic Fatty Liver Disease (NAFLD).

Laura E Dichtel, Azadeh Tabari, Nathaniel D Mercaldo, Kathleen E Corey, Jad Husseini, Stephanie A Osganian, Mark L Chicote, Elizabeth M Rao, Karen K Miller, Miriam A Bredella

Abstract read
In one paragraph

Article in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Accuracy of Non-Invasive Imaging Techniques for the Diagnosis of MASH in Patients With MASLD: A Systematic Review.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Pooled it
  2. Article
  3. Observational
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laura E DichtelHarvard Medical School, Boston, MA, USA.
Azadeh TabariDepartment of Radiology, Massachusetts General Hospital, Boston, MA, USA.
Nathaniel D MercaldoHarvard Medical School, Boston, MA, USA.
Kathleen E CoreyHarvard Medical School, Boston, MA, USA.
Jad HusseiniHarvard Medical School, Boston, MA, USA.
Stephanie A OsganianDepartment of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.
Mark L ChicoteNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
Elizabeth M RaoNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
Karen K MillerHarvard Medical School, Boston, MA, USA.
Miriam A BredellaHarvard Medical School, Boston, MA, USA.

Funding

Growth Hormone and Cardiovascular DiseaseK24HL092902 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KAREN K · 2010 to 2019
$1.6M
NHLBI NIH HHS K24 HL092902
6 · The paper itself

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease worldwide. There are limited biomarkers that can detect progression from simple steatosis to nonalcoholic steatohepatitis (NASH). The purpose of our study was to utilize CT texture analysis to distinguish steatosis from NASH. Methods: 16 patients with NAFLD (38% male, median (interquartile range): age 57 (48-64) years, BMI 37.5 (35.0-46.8) kg/m Results: By histology, 6/16 (37%) of patients had simple steatosis and 10/16 (63%) had NASH. Patients with NASH had lower entropy (median, interquartile range (IQR): 4.3 (4.1, 4.8) vs. 5.0 (4.9, 5.2), Conclusion: Our study provides preliminary evidence that CT texture analysis may serve as a novel imaging biomarker for disease activity in NAFLD and the discrimination of steatosis and NASH.

Indexed as

computed tomographynonalcoholic fatty liver disease (NAFLD)nonalcoholic steatohepatitis (NASH)texture analysis

Identifiers

PMID37693260
PMCPMC10483004

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.