ArticleRadiology. Cardiothoracic imaging2023
Association between Left Atrial Late Gadolinium Enhancement and Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis (MESA).
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Radiology. Cardiothoracic imaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00005487 (Multi-Ethnic Study of Atherosclerosis), which is not on this map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multi-Ethnic Study of Atherosclerosis (MESA)
Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Left atrial function and fibrosis in lifelong endurance athletes: a cardiac magnetic resonance imaging study.The international journal of cardiovascular imaging · 2025Article
- Is regional atrial strain a useful surrogate of regional atrial fibrosis in atrial cardiomyopathy?European heart journal. Imaging methods and practice · 2025Article
- Ablation of Ventricular and Atrial Arrhythmias in the Era of Cardiac Magnetic Resonance.Echocardiography (Mount Kisco, N.Y.) · 2025Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Tarek ZghaibFrom the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W.); Department of Epidemiology, University of Washington, Seattle, Wash (S.R.H.); and Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (S.N.).ORCID https://orcid.org/0000-0001-8348-2743
Thiago Quinaglia A C SilvaFrom the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W.); Department of Epidemiology, University of Washington, Seattle, Wash (S.R.H.); and Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (S.N.).ORCID 0000-0001-9099-3007
Bharath Ambale-VenkateshFrom the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W.); Department of Epidemiology, University of Washington, Seattle, Wash (S.R.H.); and Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (S.N.).ORCID 0000-0002-2330-2373
Eric XieFrom the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W.); Department of Epidemiology, University of Washington, Seattle, Wash (S.R.H.); and Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (S.N.).
Mohammad R OstovanehFrom the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W.); Department of Epidemiology, University of Washington, Seattle, Wash (S.R.H.); and Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (S.N.).ORCID 0000-0003-3175-3606
Mohammadali HabibiFrom the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W.); Department of Epidemiology, University of Washington, Seattle, Wash (S.R.H.); and Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (S.N.).
David A BluemkeFrom the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W.); Department of Epidemiology, University of Washington, Seattle, Wash (S.R.H.); and Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (S.N.).ORCID 0000-0002-8323-8086
Elsayed Z SolimanFrom the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W.); Department of Epidemiology, University of Washington, Seattle, Wash (S.R.H.); and Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (S.N.).ORCID 0000-0001-5632-8150
Colin O WuFrom the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W.); Department of Epidemiology, University of Washington, Seattle, Wash (S.R.H.); and Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (S.N.).ORCID 0000-0002-4514-0926
Susan R HeckbertFrom the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W.); Department of Epidemiology, University of Washington, Seattle, Wash (S.R.H.); and Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (S.N.).ORCID 0000-0002-7100-512X
Saman NazarianFrom the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W.); Department of Epidemiology, University of Washington, Seattle, Wash (S.R.H.); and Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (S.N.).ORCID 0000-0002-8369-0259
João A C LimaFrom the Departments of Medicine (T.Z., E.X.) and Cardiology (T.Z., T.Q.A.C.S., M.R.O., M.H., J.A.C.L.), Johns Hopkins University School of Medicine, 600 N Wolfe St, Blalock 524, Baltimore, MD 21287; Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, Md (B.A.V.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (D.A.B.); Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston Salem, NC (E.Z.S.); National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Md (C.O.W.); Department of Epidemiology, University of Washington, Seattle, Wash (S.R.H.); and Division of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa (S.N.).ORCID 0000-0001-8756-6995
Johns Hopkins University · USNational Institutes of Health · USUniversity of Wisconsin–Madison · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To determine the prevalence and correlates of left atrial (LA) late gadolinium enhancement (LGE) at cardiac MRI and its association with atrial fibrillation (AF) in a population-based sample from the Multi-Ethnic Study of Atherosclerosis (MESA). Materials and Methods: In this secondary post hoc analysis of the MESA cohort (ClinicalTrials.gov no. NCT00005487), participants without AF underwent LGE cardiac MRI at the fifth examination (2010-2012). LA LGE burden was quantified using the image intensity ratio technique on biplane long-axis two-dimensional (2D) LGE images without fat saturation. Survival analysis was performed with log-rank testing and Cox regression. Results: Of 1697 participants (mean age, 67 years ± 9 [SD]; 872 men), 1035 (61%) had LA LGE, and 75 (4.4%) developed AF during follow-up (median, 3.95 years). At univariable analysis, LA LGE was associated with age (β = .010 [95% CI: .005, .015], Conclusion: Although limited by the 2D LGE technique employed, LA LGE was associated with adverse atrial remodeling and helped predict AF in a multiethnic population-based sample.Clinical trial registration no. NCT00005487
Indexed as
CardiacEpidemiologyMR Imaging
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
NCT00005487ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.