ArticleEndoscopic ultrasound
Tissue amount and diagnostic yield of a novel franseen EUS-FNB and a standard EUS-FNA needle-A randomized controlled study in solid pancreatic lesions.
Article in Endoscopic ultrasound. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07012694 (A Prospective, Multicenter, Blinded, Randomized Controlled Trial Assessing the Diagnostic Yield and Tissue Adequacy of 22G Adapt Versus 22G Franseen Fine-Needle Biopsy for Solid Lesions Under Endoscopic Ultrasound Guidance), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Multicenter, Blinded, Randomized Controlled Trial Assessing the Diagnostic Yield and Tissue Adequacy of 22G Adapt Versus 22G Franseen Fine-Needle Biopsy for Solid Lesions Under Endoscopic Ultrasound Guidance
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Pooled it
- Prospective randomized study comparing Franseen 22-gaugeWorld journal of gastrointestinal endoscopy · 2025Trial
- Correlation Between Endosonography and Cytopathology in the Diagnosis of Pancreatic Masses: A Cross-Sectional Study.Iranian journal of pathology · 2026Article
- Endoscopic ultrasound-guided pancreatic duct drainage: Progress and future outlook.World journal of gastrointestinal surgery · 2025Review
- How to achieve the long-term goals of EUS training--survey on the performance of diagnostic EUS by newly trained endosonographers and analysis of the influencing factors.BMC medical education · 2025Article
- Endoscopic ultrasound-guided tissue acquisition allows a reliable proliferation assessment of small (≤20 mm) pancreatic neuroendocrine tumors.Annals of gastroenterological surgery · 2025Article
- Advances and challenges in precision imaging.The Lancet. Oncology · 2025Review
- Solid pancreatic lesions: etiology, morphology and utility of macroscopic on-site evaluation in predicting good yield of endoscopic ultrasound-guided biopsy.Przeglad gastroenterologiczny · 2025Article
- Performance evaluation of endoscopic ultrasonography needles: Experimental study.Endoscopy international open · 2024Article
- Comparative Assessment of Endoscopic Ultrasound-Guided Biopsies vs. Percutaneous Biopsies of Pancreatic Lesions: A Systematic Review and Meta-Analysis of Diagnostic Performance.Journal of clinical medicine · 2024Review
- Comparing needle types and aspiration techniques in EUS-TA to optimize diagnostic efficacy and specimen quality in patients with pancreatic lesions.Frontiers in medicine · 2024Article
- Validation of a Novel EUS-FNB-Derived Organoid Co-Culture System for Drug Screening in Patients with Pancreatic Cancer.Cancers · 2023Article
- Mutational profiling of 103 unresectable pancreatic ductal adenocarcinomas using EUS-guided fine-needle biopsy.Endoscopic ultrasoundArticle
- Clinical utility of macroscopic on-site evaluation in EUS-guided tissue acquisition for autoimmune pancreatitis: A retrospective study.Endoscopic ultrasoundArticle
- Diagnostic efficacy of cytologic smear and pathologic histology in the differential diagnosis of distal biliary stricture via EUS-guided fine-needle aspiration.Endoscopic ultrasoundArticle
- EUS-guided fine-needle biopsyEndoscopic ultrasoundArticle
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objectives: Several types of needles are available for EUS-guided tissue sampling of pancreatic lesions. Whereas fine-needle aspiration (FNA) needles typically provide cytological samples, fine-needle biopsy (FNB) needles are designed to obtain microcores with preserved tissue architecture. The aim of this study was to compare tissue amount and diagnostic yield between a modified Franseen-type FNB needle (TopGain; Medi-Globe GmbH, Grassau, Germany) and a standard FNA needle. Methods: We performed a prospective, multicenter randomized controlled study between June 2020 and September 2021, including patients with a solid pancreatic lesion referred for EUS-guided tissue sampling at 3 centers in Denmark. The patients were randomized 1:1 to either FNA needle or the novel FNB needle. Primary outcomes included the number of obtained tissue microcores and total and diagnostic tissue area. Results: Sixty-four patients were included. The median number of tissue microcores procured per pass was significantly higher in the FNB group compared with FNA (3 Conclusions: The novel Franseen-type FNB needle seems to be significantly superior to a conventional FNA needle. The results of this study underline excellent performance of crown-cut needles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.