Evidence map›Paper›PMID 37693045›Full record

ArticleBioengineering & translational medicine2023

Neuroprotective effects of an engineered

Heng Wu, Jing Wei, Xiumiao Zhao, Ying Liu, Zhihang Chen, Kehong Wei, Jiachen Lu, Wenjie Chen, Meixiu Jiang, Shengjie Li and 1 more

Open access · goldAbstract read
In one paragraph

Article in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 49 citations in OpenAlex.

  1. PsychobioticFrontiers in immunology · 2023
    Trial
  2. Neuroprotection of engineeredJournal of Zhejiang University. Science. B · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Gut Microbiome as a Source of Probiotic Drugs for Parkinson's Disease.International journal of molecular sciences · 2025
    Review
  15. Review
  16. Article
  17. Review
  18. Administration of a Next-Generation ProbioticThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  19. Review
  20. Microorganisms · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Heng WuNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine Nanchang University Nanchang Jiangxi China.
Jing WeiNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine Nanchang University Nanchang Jiangxi China.
Xiumiao ZhaoQueen Mary School Nanchang University Nanchang Jiangxi China.
Ying LiuInstitute of Life Science Nanchang University Nanchang Jiangxi China.
Zhihang ChenQueen Mary School Nanchang University Nanchang Jiangxi China.ORCID https://orcid.org/0000-0003-4715-2581
Kehong WeiQueen Mary School Nanchang University Nanchang Jiangxi China.
Jiachen LuQueen Mary School Nanchang University Nanchang Jiangxi China.
Wenjie ChenQueen Mary School Nanchang University Nanchang Jiangxi China.ORCID https://orcid.org/0000-0002-0078-3805
Meixiu JiangNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine Nanchang University Nanchang Jiangxi China.
Shengjie LiNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine Nanchang University Nanchang Jiangxi China.ORCID https://orcid.org/0000-0002-0680-2667
Tingtao ChenNational Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine Nanchang University Nanchang Jiangxi China.ORCID https://orcid.org/0000-0002-0506-8536
Nanchang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Considerable evidence suggests that insulin resistance is closely linked to Parkinson's disease (PD), leading to agents aiming at treating diabetes can be regarded as new neuroprotective strategies in PD, notably glucagon-like peptide-1 (GLP-1). However, the extremely short half-life of GLP-1 due to degradation by the ubiquitous proteolytic enzyme limits its clinical application. In this study, we engineered the recombinant integrant probiotic strain

Indexed as

E. coli Nissle 1917genetically engineered strainGLP‐1gut microbiotaParkinson's disease

Identifiers

PMID37693045
PMCPMC10487327
OpenAlexW4293053917

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.