Evidence map›Paper›PMID 37693043›Full record

ArticleBioengineering & translational medicine2023

Combined use of microbubbles of various sizes and single-transducer dual-frequency ultrasound for safe and efficient inner ear drug delivery.

Ai-Ho Liao, Chih-Hung Wang, Bo-Han Wang, Yi-Chun Lin, Ho-Chiao Chuang, Hao-Li Liu, Cheng-Ping Shih

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering & translational medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Rational Design of Inner Ear Drug Delivery Systems.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Ai-Ho LiaoGraduate Institute of Biomedical Engineering National Taiwan University of Science and Technology Taipei Taiwan.ORCID https://orcid.org/0000-0001-9101-6662
Chih-Hung WangDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital National Defense Medical Center Taipei Taiwan.ORCID https://orcid.org/0000-0001-5058-4356
Bo-Han WangDepartment of Mechanical Engineering National Taipei University of Technology Taipei Taiwan.
Yi-Chun LinGraduate Institute of Medical Sciences National Defense Medical Center Taipei Taiwan.
Ho-Chiao ChuangDepartment of Mechanical Engineering National Taipei University of Technology Taipei Taiwan.
Hao-Li LiuDepartment of Electrical Engineering National Taiwan University Taipei Taiwan.
Cheng-Ping ShihDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital National Defense Medical Center Taipei Taiwan.ORCID https://orcid.org/0000-0002-5515-2509
National Taipei University of Technology · TWTri-Service General Hospital · TWNational Defense Medical Center · TWNational Taiwan University · TWNational Taiwan University of Science and Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have previously applied ultrasound (US) with microbubbles (MBs) to enhance inner ear drug delivery, with most experiments conducted using single-frequency, high-power density US, and multiple treatments. In the present study, the treatment efficacy was enhanced and safety concerns were addressed using a combination of low-power-density, single-transducer, dual-frequency US (

Indexed as

cavitationdrug deliverydual‐frequency ultrasoundhair cellinner earinsulin‐like growth factor 1 (IGF‐1)microbubblesround window membrane

Identifiers

PMID37693043
PMCPMC10487305
OpenAlexW4309350119

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.