Minimum effective dose of oxytocin bolus during the caesarean section for patients at high vs low risk of uterine atony: A non-randomized, dual-arm, dose-finding prospective trial.

Asha Tyagi, Sonali Deep, Rashmi Salhotra, Rajeev Malhotra, Anshuja Singla

Abstract read

In one paragraph

Article in Indian journal of anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Is research reporting intraoperative hypotension apt enough?Indian journal of anaesthesia · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Asha TyagiDepartment of Anaesthesiology and Critical Care, University College of Medical Sciences and GTB Hospital, Delhi, India.

Sonali DeepDepartment of Anaesthesiology and Critical Care, University College of Medical Sciences and GTB Hospital, Delhi, India.

Rashmi SalhotraDepartment of Anaesthesiology and Critical Care, University College of Medical Sciences and GTB Hospital, Delhi, India.

Rajeev MalhotraBiostatistician, Delhi Cancer Registry, Dr. BRAIRCH, All India Institute of Medical Sciences, Delhi, India.

Anshuja SinglaDepartment of Obstetrics and Gynecology, University College of Medical Sciences and GTB Hospital, Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: There are scanty data for oxytocin dose in patients at high risk of uterine atony. We aimed to compare the effective dose (ED) 90 of oxytocin for adequate uterine tone during the caesarean section in patients at high-risk vs low-risk uterine atony. Methods: This dose-finding study was undertaken after ethical approval in non-labouring women aged >18 years with pre-defined risk factors for uterine atony (high-risk group) vs those without such factors (low-risk group) ( Results: The ED90 (95% CI) of oxytocin bolus was 4.7 (3.3-6.0) IU for the high-risk group and 2.2 (1.3-3.2) IU for the low-risk group ( Conclusion: Non-labouring patients with high-risk factors for uterine atony require a greater dose of initial oxytocin bolus to achieve adequate uterine tone during the caesarean section compared to those without risk factors.

Indexed as

Caesarean sectionhigh-risklabourminimum effective doseoxytocinuterine atony

Identifiers

PMID37693025

DOI10.4103/ija.ija_760_22

PMCPMC10488585

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.