Evidence map›Paper›PMID 37693008›Full record

ArticleFrontiers in physiology2023

FoxO3 normalizes Smad3-induced arterial smooth muscle cell growth.

Jake T Francisco, Andrew W Holt, Michael T Bullock, Madison D Williams, Cere E Poovey, Nathan A Holland, Jeffrey J Brault, David A Tulis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A.American journal of physiology. Heart and circulatory physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jake T FranciscoDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
Andrew W HoltDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
Michael T BullockDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
Madison D WilliamsDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
Cere E PooveyDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
Nathan A HollandDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
Jeffrey J BraultDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
David A TulisDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.
East Carolina University · US

Funding

NO-independent cGMP regulation of vascular remodelingR01HL081720 · NHLBI · NORTH CAROLINA CENTRAL UNIVERSITY · PI TULIS, DAVID A · 2007 to 2012
$2.2M
CELLULAR ENERGETICS AS A REGULATOR OF MUSCLE MASS AND MITOCHONDRIAL CONTENT DURING MUSCLE ATROPHYR01AR070200 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI BRAULT, JEFFREY J · 2017 to 2021
$1.6M
Acid-sensing GPCRs in vascular inflammation and growthR15HL135699 · NHLBI · EAST CAROLINA UNIVERSITY · PI TULIS, DAVID A · 2017 to 2017
$443k
NHLBI NIH HHS R01 HL081720NHLBI NIH HHS R15 HL135699NIAMS NIH HHS R01 AR070200
6 · The paper itself

Abstract

Transition of arterial smooth muscle (ASM) from a quiescent, contractile state to a growth-promoting state is a hallmark of cardiovascular disease (CVD), a leading cause of death and disability in the United States and worldwide. While many individual signals have been identified as important mechanisms in this phenotypic conversion, the combined impact of the transcription factors Smad3 and FoxO3 in ASM growth is not known. The purpose of this study was to determine that a coordinated, phosphorylation-specific relationship exists between Smad3 and FoxO3 in the control of ASM cell growth. Using a rat

Indexed as

adenoviral overexpressionarterial smooth musclecardiovascular diseaseFoxO3MuRF-1phosphorylationSmad3

Identifiers

PMID37693008
PMCPMC10483145
OpenAlexW4386138356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.