Evidence map›Paper›PMID 37692967›Full record

ReviewAmerican journal of translational research2023

Unlocking therapeutic potential: integration of drug repurposing and immunotherapy for various disease targeting.

Vishakha Anand Pawar, Anuradha Tyagi, Chaitenya Verma, Kanti Prakash Sharma, Sekhu Ansari, Indra Mani, Shailesh Kumar Srivastva, Pradeep Kumar Shukla, Antresh Kumar, Vinay Kumar

Open access · greenAbstract readReview
In one paragraph

Review in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. From Lab to Clinic: Success Stories of Repurposed Drugs in Treating Major Diseases.Advances in pharmacological and pharmaceutical sciences · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

Vishakha Anand PawarThe University of Texas MD Anderson Cancer Center Houston, TX 77030, USA.
Anuradha TyagiDepartment of cBRN, Institute of Nuclear Medicine and Allied Science Delhi 110054, India.
Chaitenya VermaDepartment of Pathology, Wexner Medical Center, Ohio State University Columbus, Ohio 43201, USA.
Kanti Prakash SharmaDepartment of Nutrition Biology, Central University of Haryana Mahendragarh 123029, India.
Sekhu AnsariDivision of Pathology, Cincinnati Children's Hospital Medical Center Cincinnati, Ohio 45229, USA.
Indra ManiDepartment of Microbiology, Gargi College, University of Delhi New Delhi 110049, India.
Shailesh Kumar SrivastvaDepartment of Zoology, Shia P.G. College Lucknow 226020, India.
Pradeep Kumar ShuklaDepartment of Biological Sciences, Faculty of Science, Sam Higginbottom University of Agriculture, Technology of Science Prayagraj 211007, UP, India.
Antresh KumarDepartment of Biochemistry, Central University of Haryana Mahendergarh 123031, Haryana, India.
Vinay KumarDepartment of Physiology and Cell Biology, The Ohio State University Wexner Medical Center Columbus, Ohio 43210, USA.
Central University of Haryana · INThe Ohio State University Wexner Medical Center · USCincinnati Children's Hospital Medical Center · USInstitute of Nuclear Medicine & Allied Sciences · INSam Higginbottom Institute of Agriculture · INThe University of Texas MD Anderson Cancer Center · USUniversity of Delhi · INUniversity of Lucknow · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug repurposing, also known as drug repositioning, entails the application of pre-approved or formerly assessed drugs having potentially functional therapeutic amalgams for curing various disorders or disease conditions distinctive from their original remedial indication. It has surfaced as a substitute for the development of drugs for treating cancer, cardiovascular diseases, neurodegenerative disorders, and various infectious diseases like Covid-19. Although the earlier lines of findings in this area were serendipitous, recent advancements are based on patient centered approaches following systematic, translational, drug targeting practices that explore pathophysiological ailment mechanisms. The presence of definite information and numerous records with respect to beneficial properties, harmfulness, and pharmacologic characteristics of repurposed drugs increase the chances of approval in the clinical trial stages. The last few years have showcased the successful emergence of repurposed drug immunotherapy in treating various diseases. In this light, the present review emphasises on incorporation of drug repositioning with Immunotherapy targeted for several disorders.

Indexed as

Cancercardiovascular diseasesCovid-19drug discoverydrug repurposingimmunotherapyinfectious disease

Identifiers

PMID37692967
PMCPMC10492070
OpenAlexW4386592935

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.