Evidence map›Paper›PMID 37692946›Full record

ArticleAmerican journal of translational research2023

The hepatitis B virus pre-core protein p22 suppresses TNFα-induced apoptosis by regulating the NF-κB pathway.

Zhihong Diao, Huan Luo, Ying Li, Zhenli Ma, Fangmei Tang, Buqing Cao, Yuqing Feng, Zhongsong Mo, Hongjun Gao

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. New Insights into the Role of NF-κB in Hepatitis B Virus Infection.International journal of biological sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zhihong DiaoDepartment of Laboratory Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning 530011, Guangxi, P. R. China.
Huan LuoDepartment of Laboratory Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning 530011, Guangxi, P. R. China.
Ying LiDepartment of Laboratory Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning 530011, Guangxi, P. R. China.
Zhenli MaDepartment of Laboratory Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning 530011, Guangxi, P. R. China.
Fangmei TangDepartment of Laboratory Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning 530011, Guangxi, P. R. China.
Buqing CaoDepartment of Laboratory Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning 530011, Guangxi, P. R. China.
Yuqing FengDepartment of Laboratory Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning 530011, Guangxi, P. R. China.
Zhongsong MoDepartment of Laboratory Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning 530011, Guangxi, P. R. China.
Hongjun GaoRuikang Hospital Affiliated to Guangxi University of Chinese Medicine Nanning 530011, Guangxi, P. R. China.
Ruikang Affiliated Hospital of Guangxi Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCell apoptosis is strongly associated with hepatocellular carcinoma (HCC) progress. Thus, gaining a comprehensive understanding of the virus interfering with the apoptotic process is important for the development of effective anti-tumor therapies. The objective of this study is to explore the potential involvement of HBeAg-p22 (HBV-p22) in TNFα-induced apoptosis.

methodsProtein expression was detected using western blot. Cell viability and apoptosis were assessed by employing Cell Counting Kit-8 (CCK8) and flow cytometry, respectively. Evaluation of protein-protein interactions was accomplished through co-immunoprecipitation and glutathione-S-transferase (GST) pull-down assays.

resultsIn this study, it was shown that HBV-p22 inhibited apoptosis of human hepatoma cell lines after tumor necrosis factor-alpha (TNF-α) stimulation. Mechanistically, HBV-p22 suppressed Jun N-terminal kinases (JNK) signaling and enhanced nuclear factor kappa-B (NF-κB) signaling. Moreover, HBV-p22 interacted with I-kappa B kinase α (IKKα) and increased its phosphorylation.

conclusionsCollectively, HBV-p22, whereby the mechanism contributing to anti-apoptotic effect was regulation of the NF-κB pathway via enhancing the phosphorylation of IKKα.

Indexed as

apoptosisHBeAg-p22Hepatitis B virushepatocellular carcinomaNF-κB signalingTNFα

Identifiers

PMID37692946
PMCPMC10492049
OpenAlexW4386593009

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.