Evidence map›Paper›PMID 37692908›Full record

ArticleNpj flexible electronics2023

A Soft, High-Density Neuroelectronic Array.

Kyung Jin Seo, Mackenna Hill, Jaehyeon Ryu, Chia-Han Chiang, Iakov Rachinskiy, Yi Qiang, Dongyeol Jang, Michael Trumpis, Charles Wang, Jonathan Viventi and 1 more

Abstract read
In one paragraph

Article in Npj flexible electronics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kyung Jin SeoThayer School of Engineering, Dartmouth College, Hanover, NH 03755.
Mackenna HillDepartment of Biomedical Engineering, Duke University, Durham, NC 27708.
Jaehyeon RyuThayer School of Engineering, Dartmouth College, Hanover, NH 03755.
Chia-Han ChiangDepartment of Biomedical Engineering, Duke University, Durham, NC 27708.
Iakov RachinskiyDepartment of Biomedical Engineering, Duke University, Durham, NC 27708.
Yi QiangThayer School of Engineering, Dartmouth College, Hanover, NH 03755.
Dongyeol JangThayer School of Engineering, Dartmouth College, Hanover, NH 03755.
Michael TrumpisDepartment of Biomedical Engineering, Duke University, Durham, NC 27708.
Charles WangDepartment of Biomedical Engineering, Duke University, Durham, NC 27708.
Jonathan ViventiDepartment of Biomedical Engineering, Duke University, Durham, NC 27708.
Hui FangThayer School of Engineering, Dartmouth College, Hanover, NH 03755.

Funding

Optimizing flexible, active electrode arrays for chronic, large-scale recording and stimulation on the scale of 100,000 electrodesU01NS099697 · NINDS · DUKE UNIVERSITY · PI BRAUN, PAUL, PESARAN, BIJAN · 2016 to 2018
$3.5M
Neuro-CROWN:Optimized Ultra-Flexible CMOS Electrode Arrays for 3D, Low-Noise Neural InterfacesU01NS123668 · NINDS · DUKE UNIVERSITY · PI FANG, HUI, VIVENTI, JONATHAN · 2021 to 2024
$2.9M
Massively Multiplexed Gold Microprobe Arrays for Whole-Mouse-Brain RecordingR21EY030710 · NEI · NORTHEASTERN UNIVERSITY · PI FANG, HUI, WALKER, ROSS M · 2019 to 2019
$479k
NEI NIH HHS R21 EY030710NINDS NIH HHS U01 NS099697NINDS NIH HHS U01 NS123668
6 · The paper itself

Abstract

Techniques to study brain activities have evolved dramatically, yet tremendous challenges remain in acquiring high-throughput electrophysiological recordings minimally invasively. Here, we develop an integrated neuroelectronic array that is filamentary, high-density and flexible. Specifically, with a design of single-transistor multiplexing and current sensing, the total 256 neuroelectrodes achieve only a 2.3 × 0.3 mm2 area, unprecedentedly on a flexible substrate. A novel single-transistor multiplexing acquisition circuit further reduces noise from the electrodes, decreased the footprint of each pixel, and potentially increased the device lifetime. The filamentary neuroelectronic array also integrates with a rollable contact pad design, allowing the device to be injected through a syringe, enabling potential minimally invasive array delivery. Successful acute auditory experiments in rats validate the ability of the array to record neural signals with high tone decoding accuracy. Together, these results establish soft, high-density neuroelectronic arrays as promising devices for neuroscience research and clinical applications.

Identifiers

PMID37692908
PMCPMC10487278

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.